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Protection of natural infection against reinfection with SARS-CoV-2 JN.1 variant
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Date
2024-05-01
Author
Chemaitelly, Hiam, Coyle, Peter, Kacem, Mohamed Ali Ben, Ayoub, Houssein H., Tang, Patrick, Hasan, Mohammad R., Yassine, Hadi M., Al Thani, Asmaa A., Al-Kanaani, Zaina, Al-Kuwari, Einas, Jeremijenko, Andrew, Kaleeckal, Anvar H., Latif, Ali N., Shaik, Riyazuddin M., Abdul-Rahim, Hanan F., Nasrallah, Gheyath K., Al-Kuwari, Mohamed Ghaith, Butt, Adeel A., Al-Romaihi, Hamad E., Al-Thani, Mohamed H., Al-Khal, Abdullatif, Bertollini, Roberto, Abu-Raddad, Laith J.
Abstract
Evidence at the level of neutralizing antibodies suggests that the SARS-CoV-2 JN.1 variant demonstrates increased immune evasion compared to its parent lineage BA.2.86 and to recently circulating variants, such as XBB.1.5 and EG.5.1.1 JN.1 has also exhibited a growth advantage over other variants and triggered large SARS-CoV-2 waves in various countries,2 prompting the World Health Organization to classify it as a variant of interest on 19 December 2023.2 We estimated the effectiveness of natural infection in preventing reinfection with JN.1 during a large JN.1 wave in Qatar using the test-negative case-control study design.3,4