Loading...
Duration of mRNA vaccine protection against SARS-CoV-2 Omicron BA.1 and BA.2 subvariants in Qatar.
Citations
Altmetric:
Video URL
Date
2022-06-02
Author
Chemaitelly, Hiam, Ayoub, Houssein H, AlMukdad, Sawsan, Coyle, Peter, Tang, Patrick, Yassine, Hadi M, Al-Khatib, Hebah A, Smatti, Maria K, Hasan, Mohammad R, Al-Kanaani, Zaina, Al-Kuwari, Einas, Jeremijenko, Andrew, Kaleeckal, Anvar Hassan, Latif, Ali Nizar, Shaik, Riyazuddin Mohammad, Abdul-Rahim, Hanan F, Nasrallah, Gheyath K, Al-Kuwari, Mohamed Ghaith, Butt, Adeel A, Al-Romaihi, Hamad Eid, Al-Thani, Mohamed H, Al-Khal, Abdullatif, Bertollini, Roberto, Abu-Raddad, Laith J
Files
Loading...
s41467-022-30895-3.pdf
Adobe PDF, 1.68 MB
Abstract
SARS-CoV-2 Omicron BA.1 and BA.2 subvariants are genetically divergent. We conducted a matched, test-negative, case-control study to estimate duration of protection of the second and third/booster doses of mRNA COVID-19 vaccines against BA.1 and BA.2 infections in Qatar. BNT162b2 effectiveness was highest at 46.6% (95% CI: 33.4-57.2%) against symptomatic BA.1 and at 51.7% (95% CI: 43.2-58.9%) against symptomatic BA.2 infections in the first three months after the second dose, but declined to ~10% or below thereafter. Effectiveness rebounded to 59.9% (95% CI: 51.2-67.0%) and 43.7% (95% CI: 36.5-50.0%), respectively, in the first month after the booster dose, before declining again. Effectiveness against COVID-19 hospitalization and death was 70-80% after the second dose and >90% after the booster dose. mRNA-1273 vaccine protection showed similar patterns. mRNA vaccines provide comparable, moderate, and short-lived protection against symptomatic BA.1 and BA.2 Omicron infections, but strong and durable protection against COVID-19 hospitalization and death.