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Synthesis and biological testing of 2,4-disubstituted thiazole derivatives as Potential antitumor antibiotics

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Date
1994
Author
El Subbagh, H. I. [ح. الصباخ], El-Naggar, W. A., Badria, F. A.
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Qatar University Science Journal - [From 1981 TO 2007]
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Synthesis and biological testing of 2,4-disubstituted thiazole derivatives as potential antitumor antibiotics.pdf
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Abstract
A series of thiazole derivatives bearing amino, acetamido or thioureido synthons at position 2- and thiosemicarbazone or 1,2,4-triazolethione moieties at position 4- have been synthesized and evaluated for their antimicrobial and antitumor activities. Some of the tested compounds (5,6,14 and 15) proved to possess ^remarkable antitumor antibiotic activity. The antimicrobial potency is found mainly to be against Gram positive bacterfa. The detailed synthesis, spectroscopic and biological data are reported.
URI
http://hdl.handle.net/10576/9645