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Lipid-Rich Carcinoma of the Breast: A Rare but Aggressive Mammary Malignancy

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Date
2026
Author
Tluli, Omar, Babu, Giridhara Rathnaiah, Vranic, Semir
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Medicine Research
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Abstract
Breast cancer is a complex and heterogeneous disease encompassing various morphologic and molecular subtypes (1). Invasive ductal carcinoma of no special type is the most common morphologic subtype of breast cancer. Within this subtype, the World Health Organization classification of breast cancers recognizes several rare morphologic patterns, including the lipid-rich variant of breast carcinoma (LRBC) (1). It is characterized by the neoplastic proliferation of cells enriched with neutral lipids in their cytoplasm, irregular nuclei exhibiting marked atypia, and frequent mitoses (1). LRBC appears to be extremely rare, with only around 100 cases published up to mid-2025 (2-4). Based on the Surveillance, Epidemiology, and End Results (SEER) analysis up to 2021, we identified 15 new LRBCs among approximately three million breast cancer patients, corresponding to ~0.001% of all breast cancer cases. Table 1 summarizes the demographic features, tumor characteristics, treatment details, and survival outcomes of the LRBC cohort.
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http://hdl.handle.net/10576/71318