Heterocyclo-sulpha drugs: part x. Novel 5-imino-a2-pyrazolin-4-ditfflocarbamyl-s-azo dyes as antimicrobial agents
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Synthesis of a series of novel azo-sulpha drugs as 5-imino-3-methyl-l-phenyl-A -pyrazolin-4-dithiocarbamyl-s-azo dyes (I-XV) are described by the reaction of 4-sulphamoyl and/or sulphonyl diazonium chloride with 5-imino-3-methyl-1-phenyl-A -pyrazolin-4-dithiocarbamic acid in acid medium. The corresponding iron, copper, mercury, cobalt, nickel and lead chelates are synthesized, in 1:1 ligand-to-metal cation molar ratio on cold giving monochelate compounds (Ia-f-XVa-f)- Furthermore, in 1:2 molar ratio on hot gave dichelate compounds (I'a-f-XV's-f). All the synthesized azo-sulpha drugs (ligands) and their mono-and/or dichelates are characterized by microanalysis, UV, IR and 'H-NMR spectroscopy and screened in vitro for their antibacterial and antifungal activities.
- Qatar University Science Journal - [From 1981 TO 2007] [770 items ]