Show simple item record

AuthorShi, Zumin
AuthorJi, Linong
AuthorMa, Ronald C W
AuthorZimmet, Paul
Available date2019-08-29T10:11:56Z
Publication Date2019-08-01
Publication NameJournal of Diabetes
Identifierhttp://dx.doi.org/10.1111/1753-0407.12975
CitationShi Z, Ji L, Ma RCW, Zimmet P. Early life exposure to 1959-1961 Chinese famine exacerbates association between diabetes and cardiovascular disease. Journal of Diabetes. 2019; 1–8. https://doi.org/10.1111/1753-0407.12975
ISSN1753-0393
IdentifierZumin Shi https://orcid.org/0000-0002-3099-3299
IdentifierLinong Ji https://orcid.org/0000-0002-3262-2168
URIhttp://hdl.handle.net/10576/11762
AbstractWe aimed to assess whether early life exposure to the Chinese famine (1959-1961) modifies the association between type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) in adulthood. Data from 4247 adults born between 1954 and 1964 from the 2011 and 2015 China Health and Retirement Longitudinal Study (CHARLS) were analysed. CVD in 2011 and 2015 was based on self-reported doctor's diagnosis of cardiac events (heart attack, coronary heart disease, angina, congestive heart failure, or other heart problems) and stroke. Diabetes in 2011 was defined by fasting blood glucose, HbA1C or known diabetes. Diabetes in 2011 was cross-sectionally associated with an increase of CVD risk in 2011 (OR 1.91, 95%CI 1.53-2.40, P < 0.001) after adjusting for age and gender. Famine exposure changed the association between diabetes and CVD in areas severely affected by famine. The odds ratio (OR) of diabetes in 2011 for CVD in 2015 were: 1.24 (95%CI 0.73-2.10), 1.27 (95%CI 0.72-2.24), 2.25 (95%CI 1.29-3.91), 4.31 (95%CI 2.07-8.97) and 1.72 (95%CI 0.84-3.51) among adults in late childhood-, mid childhood-, early childhood-, fetal-, and non-exposed cohorts in severe famine areas, respectively. T2DM is associated with the risk of CVD among Chinese adults. Fetal and early childhood exposure to the Chinese famine exacerbated the associated risk. This article is protected by copyright. All rights reserved.
Languageen
PublisherWiley
SubjectChinese
Famine
adults
cardiovascular disease
type 2 diabetes
TitleEarly life exposure to 1959-1961 Chinese famine exacerbates association between diabetes and cardiovascular disease.
TypeArticle
ESSN1753-0407
dc.accessType Abstract Only


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record