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المؤلفKhadija M., Zadeh
المؤلفLuyt, Adriaan S.
المؤلفZarif, Lubna
المؤلفAugustine, Robin
المؤلفHasan, Anwarul
المؤلفMessori, Massimo
المؤلفHassan, Mohammad K.
المؤلفYalcin, Huseyin C.
تاريخ الإتاحة2019-09-18T06:08:36Z
تاريخ النشر2019-07-26
اسم المنشورEmergent Materialsen_US
المعرّفhttp://dx.doi.org/10.1007/s42247-019-00042-8
الاقتباسZadeh, K.M., Luyt, A.S., Zarif, L. et al. emergent mater. (2019) 2: 141. https://doi.org/10.1007/s42247-019-00042-8
الرقم المعياري الدولي للكتاب2522-5731
معرّف المصادر الموحدhttp://hdl.handle.net/10576/11882
الملخصIn this study, a set of polylactic acid (PLA)/polyphenol extracted from date palm fruit (DP) blends were prepared by electrospinning process to be used as cell culture scaffolds for tissue engineering applications. For this purpose, PLA/DP blends with variable composition were dissolved in dichloromethane/dimethylformamide (70:30, v/v) mixture and then electrospun to obtain the fibres. Contact angle measurements, dynamic mechanical analysis, mechanical tensile and scanning electron microscopy (SEM) tools were used to study the physico-mechanical properties of the electrospun scaffolds. The results revealed that scaffolds became more hydrophilic with addition of DP. Increasing the polyphenol concentration caused the tensile strength and Young’s modulus to decrease. The SEM graphs indicated a decrease in fibre diameter with increasing DP content. In addition, it was found that both cell proliferation and cell viability were enhanced with increased DP concentration within the scaffolds. The scratch test shows that there is an enhancement in cell migration through the scratch for PLA/DP scaffolds; again, higher DP content resulted better migration. Our results suggest that improved mechanical properties, decreased fibre diameter and enhanced hydrophilicity with addition of DP improved cell migration and cell adhesion for the scaffolds. Overall, these results demonstrate that DP is a potential natural cell-friendly product for tissue engineering applications such as tissue regeneration or wound healing assays.
اللغةen
الناشرSpringer
الموضوعDate palm fruit
الموضوعPolylactic acid/polyphenol blend
الموضوعElectrospinning
الموضوعScaffold
الموضوعCell adhesion
الموضوعTissue engineering
العنوانElectrospun polylactic acid/date palm polyphenol extract nanofibres for tissue engineering applications
النوعArticle
الصفحات141–151
رقم العدد2
رقم المجلد2
dc.identifier.essn 2522-574X


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