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AuthorElkhalifa, Dana
AuthorAlali, Feras
AuthorAl Moustafa, Ala-Eddin
AuthorKhalil, Ashraf
Available date2019-10-16T06:09:36Z
Publication Date2019-09-01
Publication NameJournal of Drug Targetingen_US
Identifierhttp://dx.doi.org/10.1080/1061186X.2018.1561889
CitationSteven Rhodes, Spencer Short, Sidhika Sharma, Ramneet Kaur, Mukund Jha. (2019) One-pot mild and efficient synthesis of [1,3]thiazino[3,2- a ]indol-4-ones and their anti-proliferative activity. Organic & Biomolecular Chemistry 17:16, pages 3914-3920
ISSN1061-186X
URIhttp://hdl.handle.net/10576/12125
AbstractTriple negative breast cancers (TNBCs) are aggressive heterogeneous cancers with not yet determined conventional targeted medication. Therefore, identification of new alternatives or improved treatment options to combat this deadly disease is highly needed. On the other hand, various derived products with chalcone scaffold were historically considered excellent candidates for the development of anticancer drugs. Chalcones unique chemical structure and their substantial biological activities in cancer cells make them an extremely attractive target for the treatment of several human carcinomas including TNBCs. This review highlights the promising therapeutic role of chalcones in TNBC management.
Languageen
PublisherInforma Healthcare
SubjectChalcone
Subjectheterogeneity
Subjectmetastasis
Subjectmolecular targets
Subjecttriple negative breast cancer (TNBC)
TitleTargeting triple negative breast cancer heterogeneity with chalcones: a molecular insight.
TypeArticle Review
Pagination830-838
Issue Number8
Volume Number27
ESSN1029-2330


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