|Abstract||Fourier Transform Infrared Spectroscopy (FTIR) is a non-destructive analytical technique that has been employed in this research to characterize the biochemical make-up of various rat brain regions. The sensorimotor cortex, caudate putamen, thalamus, and the hippocampus were found to have higher olefinic content-an indicator of a higher degree of unsaturated fatty acids-rich in short-chain fatty acids, and low in ester and lipid contents. While the regions of the corpus callosum, internal, and external capsule were found to contain long-chained and higher-esterified saturated fatty acids. These molecular differences may reflect the roles of the specific regions in information processing and can provide a unique biochemical platform for future studies on the earlier detection of pathology development in the brain, as a consequence of disease or injury. Laser Ablation Inductively Coupled Plasma Mass Spectroscopy (LA-ICP-MS) is another vital analytical technique that was used in this work to analyze the elements' distribution patterns in various regions of the brain. The complementary data sets allowed the characterization of the brain regions, the chemical dominating groups, and the elemental composition. This set-up may be used for the investigation of changes in the brain caused by diseases and help create a deeper understanding of the interactions between the organic and elemental composition. � 2018 by the authors.
|Sponsor||Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Doha 34110, Qatar; email@example.com Department of Chemistry and Earth Sciences, Qatar University, Doha 2713, Qatar; firstname.lastname@example.org (F.R.); email@example.com (A.M.S.); firstname.lastname@example.org (K.A.-S.) Forschungszentrum J�lich GmbH, Zentralinstitut f�r Engineering, 52425 Elektronik und Analytik, Germany; email@example.com (V.N.); firstname.lastname@example.org (S.K.) Qatar Computing Research Institute (QCRI), Hamad Bin Khalifa University, Doha 34110, Qatar; email@example.com (E.U.); firstname.lastname@example.org (R.M.) Central Laboratories Unit, Qatar University, Doha 2713, Qatar; email@example.com Chemical Engineering Program, Texas A&M University at Qatar, Doha 23874, Qatar; firstname.lastname@example.org Centre for Biospectroscopy and the School of Chemistry, Monash University, Clayton, Victoria 3800, Australia; email@example.com Correspondence: firstname.lastname@example.org