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Authorbawadi, Hiba
Authoratkhouda, Rami
AuthorTayyem, Reema
AuthorKerkadi1, Abdelhamid
AuthorSamira, Bou Raad
AuthorSubih, Hadil
Available date2019-12-01T10:29:19Z
Publication Date2019
Publication NameDove Pressen_US
CitationBawadi et. al. Abdominal Fat Is Directly Associated With Inflammation In Persons With Type-2 Diabetes Regardless Of Glycemic Control – A Jordanian Study. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2019:12 2411–2417
URIhttp://hdl.handle.net/10576/12342
AbstractBackground and aim: Systemic inflammation is related to the progression of complications associated with diabetes. This study aimed to investigate the association between general and abdominal obesity and inflammation in patients with type-2 diabetes with or without glycemic control. Methods: A total of 198 men (n=73) and women (n=125) diagnosed with type 2 diabetes participated in this study. General obesity markers, body mass index (BMI), and abdominal fat were assessed. Circulating concentrations of glycated hemoglobin (HbA1C), C-reactive protein (CRP), and serum interleukin-6 (IL-6) were determined. Poor glycemic control and good glycemic control were defined as having fasting HbA1C concentrations ≥7% and <7%, respectively. Multivariate adjusted analysis of covariance was used to determine the relation between BMI and abdominal fat and markers of inflammation in patients with good and poor glycemic control. Results: Patients in <7% HbA1C category, those with high abdominal fat had ≈262% higher CRP and ≈30.6% higher IL-6 compared to those with low abdominal fat (p˂0.05). Patients in ≥7% HbA1C category, those with high abdominal fat had ≈41.4% higher CRP and ≈33.9% higher IL-6 compared to those with low abdominal fat (p˂0.05). Abdominal fat was directly related to CRP (p˂0.023) and IL-6 (p˂0.002) concentrations in both groups of type-2 diabetic patients with <7% and ≥7% HbA1C. In patients with ≥7% HbA1C, BMI was directly related to CRP (p˂0.02) and IL-6 (p˂0.047). Whereas in patients with <7% HbA1C, BMI was not associated with CRP or IL-6 concentrations. Conclusion: High level of abdominal fat is associated with systemic inflammation in type-2 diabetes regardless of glycemic control. Abdominal fat is a better predictor (determinant) of inflammation than BMI in patients with type-2 diabetes with or without glycemic control. Keywords: BMI, C-reactive protein, diabetes, IL-6, inflammation, obesity
SponsorThis research is funded by Jordan University of Science and Technology
Languageen
SubjectBMI
SubjectC-reactive protein
Subjectdiabetes
Subjectinflammation
TitleAbdominal Fat Is Directly Associated With Inflammation In PersonsWith Type-2 Diabetes Regardless Of Glycemic Control – A Jordanian Study
TypeArticle


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