Show simple item record

AuthorSherbash, Mohamed
AuthorFuruya-Kanamori, Luis
AuthorNader, Joanne Daghfal
AuthorThalib, Lukman
Available date2020-03-24T04:20:35Z
Publication Date2020
Publication NameBMC Pulmonary Medicine
Identifierhttp://dx.doi.org/10.1186/s12890-020-1102-5
CitationSherbash, M., Furuya-Kanamori, L., Nader, J.D. et al. Risk of wheezing and asthma exacerbation in children treated with paracetamol versus ibuprofen: a systematic review and meta-analysis of randomised controlled trials. BMC Pulm Med 20, 72 (2020). https://doi.org/10.1186/s12890-020-1102-5
ISSN1471-2466
URIhttp://hdl.handle.net/10576/13485
AbstractBackground Paracetamol and ibuprofen are the most commonly used medications for fever and pain management in children. While the efficacy appears similar with both drugs, there are contradictory findings related to adverse events. In particular, incidence of wheezing and asthma among children taking paracetamol compared to ibuprofen, remain unsettled. Methods We conducted a meta-analysis of randomized controlled trials (RCTs) that compared wheezing and asthma exacerbations in children taking paracetamol versus ibuprofen. A comprehensive search was conducted in five databases. RCTs reporting on cases of wheezing or asthma exacerbations in infants or children after the administration of paracetamol or ibuprofen were included. The pooled effect size was estimated using the Peto’s odds ratio. Results Five RCTs with 85,095 children were included in the analysis. The pooled estimate (OR 1.05; 95%CI 0.76–1.46) revealed no difference in the odds of developing asthma or presenting an exacerbation of asthma in children who received paracetamol compared to ibuprofen. When the analysis was restricted to RCTs that examined the incidence of asthma exacerbation or wheezing, the pooled estimate remained similar (OR 1.01; 95%CI 0.63–1.64). Additional bias adjusted quality effect sensitivity model yielded similar results (RR 1.03; 95%CI 0.84–1.28). Conclusion Although, Ibuprofen and paracetamol appear to have similar tolerance and safety profiles in terms of incidence of asthma exacerbations in children, we suggest high quality trials with clear definition of asthma outcomes after receiving ibuprofen or paracetamol at varying doses with longer follow-up are warranted for any conclusive finding
SponsorThe publication of this article was funded by the Qatar National Library. The funding body had no role in study design, data collection, data analysis, data interpretation or writing of the manuscript.
Languageen
PublisherBMC
SubjectParacetamol
Acetaminophen
Ibuprofen
Wheezing
Asthma
Meta-analysis
TitleRisk of wheezing and asthma exacerbation in children treated with paracetamol versus ibuprofen: a systematic review and meta-analysis of randomised controlled trials
TypeArticle
Issue Number1
Volume Number20
dc.accessType Open Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record