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AuthorAshammakhi N.
AuthorHasan A.
AuthorKaarela O.
AuthorByambaa B.
AuthorSheikhi A.
AuthorGaharwar A.K.
AuthorKhademhosseini A.
Available date2020-04-09T12:27:28Z
Publication Date2019
Publication NameAdvanced Healthcare Materials
ResourceScopus
ISSN21922640
URIhttp://dx.doi.org/10.1002/adhm.201801048
URIhttp://hdl.handle.net/10576/13989
AbstractThree-dimensional (3D) bioprinting of cell-laden biomaterials is used to fabricate constructs that can mimic the structure of native tissues. The main techniques used for 3D bioprinting include microextrusion, inkjet, and laser-assisted bioprinting. Bioinks used for bone bioprinting include hydrogels loaded with bioactive ceramics, cells, and growth factors. In this review, a critical overview of the recent literature on various types of bioinks used for bone bioprinting is presented. Major challenges, such as the vascularity, clinically relevant size, and mechanical properties of 3D printed structures, that need to be addressed to successfully use the technology in clinical settings, are discussed. Emerging approaches to solve these problems are reviewed, and future strategies to design customized 3D printed structures are proposed.
SponsorThe authors acknowledge funding from the National Institutes of Health (AR057837) and National Priority Research program, Part of Qatar Foundation, (NPRP9-144-03-021 and NPRP10-120-170211). All statements made herein are solely the responsibility of the authors. The authors also thank Mohammed Xohdy for drawing Figures 2 and 4.
Languageen
PublisherWiley-VCH Verlag
Subject3D bioprinting
bioinks
bone defects
tissue engineering
TitleAdvancing Frontiers in Bone Bioprinting
TypeArticle Review
Issue Number7
Volume Number8
dc.accessType Abstract Only


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