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AuthorGandra U.R.
AuthorSinopoli A.
AuthorMoncho S.
AuthorNandakumar M.
AuthorNinkovi? D.B.
AuthorZari? S.D.
AuthorSohail M.
AuthorAl-Meer S.
AuthorBrothers E.N.
AuthorMazloum N.A.
AuthorAl-Hashimi M.
AuthorBazzi H.S.
Available date2020-04-15T12:01:43Z
Publication Date2019
Publication NameACS Applied Materials and Interfaces
ResourceScopus
ISSN19448244
URIhttp://dx.doi.org/10.1021/acsami.9b12628
URIhttp://hdl.handle.net/10576/14189
AbstractCarbon monoxide (CO) is an important biological gasotransmitter in living cells. Precise spatial and temporal control over release of CO is a major requirement for clinical application. To date, the most reported carbon monoxide releasing materials use expensive fabrication methods and require harmful and poorly designed tissue-penetrating UV irradiation to initiate the CO release precisely at infected sites. Herein, we report the first example of utilizing a green light-responsive CO-releasing polymer P synthesized via ring-opening metathesis polymerization. Both monomer M and polymer P were very stable under dark conditions and CO release was effectively triggered using minimal power and low energy wavelength irradiation (550 nm, ?28 mW). Time-dependent density functional theory (TD-DFT) calculations were carried out to simulate the electronic transition and insight into the nature of the excitations for both L and M. TD-DFT calculations indicate that the absorption peak of M is mainly due to the excitation of the seventh singlet excited state, S7. Furthermore, stretchable materials using polytetrafluoroethylene (PTFE) strips based on P were fabricated to afford P-PTFE, which can be used as a simple, inexpensive, and portable CO storage bandage. Insignificant cytotoxicity as well as cell permeability was found for M and P against human embryonic kidney cells. Copyright - 2019 American Chemical Society.
SponsorThe authors gratefully acknowledge the support of this work from the Qatar National Research Fund project number: NPRP X-095-1-024.
Languageen
PublisherAmerican Chemical Society
Subjectcarbon monoxide (CO)
CO-releasing material (CORMat)
light-responsive
polymer conjugates
portable CO storage and CO release bandage
TitleGreen Light-Responsive CO-Releasing Polymeric Materials Derived from Ring-Opening Metathesis Polymerization
TypeArticle
Pagination34376-34384
Issue Number37
Volume Number11


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