Green Light-Responsive CO-Releasing Polymeric Materials Derived from Ring-Opening Metathesis Polymerization
Author | Gandra U.R. |
Author | Sinopoli A. |
Author | Moncho S. |
Author | Nandakumar M. |
Author | Ninkovi? D.B. |
Author | Zari? S.D. |
Author | Sohail M. |
Author | Al-Meer S. |
Author | Brothers E.N. |
Author | Mazloum N.A. |
Author | Al-Hashimi M. |
Author | Bazzi H.S. |
Available date | 2020-04-15T12:01:43Z |
Publication Date | 2019 |
Publication Name | ACS Applied Materials and Interfaces |
Resource | Scopus |
ISSN | 19448244 |
Abstract | Carbon monoxide (CO) is an important biological gasotransmitter in living cells. Precise spatial and temporal control over release of CO is a major requirement for clinical application. To date, the most reported carbon monoxide releasing materials use expensive fabrication methods and require harmful and poorly designed tissue-penetrating UV irradiation to initiate the CO release precisely at infected sites. Herein, we report the first example of utilizing a green light-responsive CO-releasing polymer P synthesized via ring-opening metathesis polymerization. Both monomer M and polymer P were very stable under dark conditions and CO release was effectively triggered using minimal power and low energy wavelength irradiation (550 nm, ?28 mW). Time-dependent density functional theory (TD-DFT) calculations were carried out to simulate the electronic transition and insight into the nature of the excitations for both L and M. TD-DFT calculations indicate that the absorption peak of M is mainly due to the excitation of the seventh singlet excited state, S7. Furthermore, stretchable materials using polytetrafluoroethylene (PTFE) strips based on P were fabricated to afford P-PTFE, which can be used as a simple, inexpensive, and portable CO storage bandage. Insignificant cytotoxicity as well as cell permeability was found for M and P against human embryonic kidney cells. Copyright - 2019 American Chemical Society. |
Sponsor | The authors gratefully acknowledge the support of this work from the Qatar National Research Fund project number: NPRP X-095-1-024. |
Language | en |
Publisher | American Chemical Society |
Subject | carbon monoxide (CO) CO-releasing material (CORMat) light-responsive polymer conjugates portable CO storage and CO release bandage |
Type | Article |
Pagination | 34376-34384 |
Issue Number | 37 |
Volume Number | 11 |
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