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AuthorZahid A.A.
AuthorAhmed R.
AuthorUr Rehman S.R.
AuthorAugustine R.
AuthorHasan A.
Available date2020-04-27T08:34:22Z
Publication Date2019
Publication NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ResourceScopus
ISSN1557170X
URIhttp://dx.doi.org/10.1109/EMBC.2019.8856469
URIhttp://hdl.handle.net/10576/14600
AbstractPoor proliferation and migration of fibroblast, keratinocyte and endothelial cells delays the wound healing in diabetic patients and results into chronicity of wounds. Slow or decreased formation of blood vessels is another issue that increases the chronicity of non-healing wounds. These chronic wounds turn into an ulcer that may lead to limb amputation. Recently, nitric oxide (NO) has emerged as a potential agent for accelerating cell migration and proliferation to enhance wound healing. It increases the expression of necessary angiogenic growth factors which stimulates the proliferation and migration of major cell types involved in wound repair. Here we report the synthesis of chitosan (CS), polyvinyl alcohol (PVA) and a NO donor S-nitroso-N-acetyl-DL-penicillamine (SNAP) to enhance the wound healing activities in chronic wounds. A three-fold increase in the proliferation of 3T3 cells was observed with NO-releasing CS-PVA hydrogels. In vitro cell migration assay demonstrated a four-fold faster migration of cells to the scratched area compared to the control group. The results depict that the use of CS-PVA hydrogel impregnated with the NO donor (SNAP) can be a promising material for promoting cell migration and subsequent accelerated healing of the chronic wounds in burns and diabetic patients. - 2019 IEEE.
SponsorThis article was made possible by the NPRP9-144-3-021 grant funded by the Qatar National Research Fund (a part of Qatar Foundation).
Languageen
PublisherInstitute of Electrical and Electronics Engineers Inc.
SubjectNitric oxide
Nitric Oxide Donors
Oxide release
TitleReactive Nitrogen Species Releasing Hydrogel for Enhanced Wound Healing
TypeConference Paper
Pagination3939-3942
dc.accessType Abstract Only


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