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AuthorElrayess, Mohamed A.
AuthorRizk, Nasser M.
AuthorFadel, Amina S.
AuthorKerkadi, Abdelhamid
Available date2020-07-19T11:48:52Z
Publication Date2020-07-15
Publication NameInternational Journal of Environmental Research and Public Healthen_US
Identifierhttp://dx.doi.org/10.3390/ijerph17145088
CitationElrayess, M.A.; Rizk, N.M.; Fadel, A.S.; Kerkadi, A. Prevalence and Predictors of Insulin Resistance in Non-Obese Healthy Young Females in Qatar. Int. J. Environ. Res. Public Health 2020, 17, 5088
ISSN1661-7827
Identifier5088
URIwww.mdpi.com/journal/ijerph
URIhttp://hdl.handle.net/10576/15294
AbstractThe state of Qatar suffers from diabetes epidemic due to obesity-associated metabolic syndrome. However, the prevalence of insulin resistance prior to obesity, which could play an important role in the high prevalence of diabetes, has not yet been described. This study aims to compare the prevalence of insulin resistance in apparently healthy non-obese and obese participants from Qatar and identify the predictors of insulin resistance in different body massindex(BMI)-groups. In this cross-sectional study, 150 young healthy females from Qatar were dichotomized into four groups (underweight, normal weight, overweight and obese) based on their BMI. Anthropometric measures as well as fasting plasma levels of lipids, adipokines, blood glucose and insulin were recorded. The prevalence of insulin resistance as per homeostatic model assessment of insulin resistance (HOMA-IR) was estimated and differences between insulin sensitive and insulin resistant were compared. Linear models were used to identify predictors of insulin resistance in every BMI group. Prevalence of insulin resistance in non-obese healthy females from Qatar ranges between 7% and 37%and increases with BMI. Overall, predictors of insulin resistance in the Qatari population are triglycerides/high-density lipoprotein (HDL) ratio and free fat mass but vary according to the BMI group. The main predictors were triglycerides in normal weight, triglycerides/HDL in overweight and triglycerides/HDL and interleukin-6 (IL-6) in obese individuals. The high prevalence of insulin resistance in non-obese Qataris may partially explain diabetes epidemic. Larger studies are warranted to confirm these findings and identify underlying causes for insulin resistance in non-obese individuals in Qatar, aiming at targeted intervention before diabetes onset
SponsorThis project was funded by Qatar University (grant number QUST-CAS-FALL-14\15-35). The publication of this article was funded by the Qatar National Library.
Languageen
PublisherMDPI
Subjectnon-obese
Subjectinsulin resistance
Subjectprevalence
SubjectBMI
SubjectQatar
TitlePrevalence and Predictors of Insulin Resistance in Non-Obese Healthy Young Females in Qatar
TypeArticle
Volume Number17
ESSN1660-4601


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