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AuthorGuo, Li
AuthorShi, Zumin
AuthorZhang, Ya
AuthorWang, Cuicui
AuthorDo Vale Moreira, Nayla Cristina
AuthorZuo, Hui
AuthorHussain, Akhtar
Available date2020-08-19T06:47:36Z
Publication Date2020-07-01
Publication NameDiabetes Research and Clinical Practice
Identifierhttp://dx.doi.org/10.1016/j.diabres.2020.108346
CitationGuo, L., Shi, Z., Zhang, Y., Wang, C., Moreira, N. C. D. V., Zuo, H., & Hussain, A. (2020). Comorbid diabetes and the risk of disease severity or death among 8807 COVID-19 patients in China: a meta-analysis. Diabetes research and clinical practice, 108346.
ISSN0168-8227
URIhttp://hdl.handle.net/10576/15690
AbstractDiabetes mellitus has been reported to be one of the most prevalent comorbidity in patients with Coronavirus Disease 2019 (COVID-19). We aimed to assess the association of comorbid diabetes with COVID-19 severity or mortality in China. We performed a systematic literature search from six electronic databases on diabetes and COVID-19. The outcome of interest was disease severity or mortality. Heterogeneity among the studies was assessed by the Cochran Q test and the I statistic. A random effects model was applied to calculate the pooled risk ratio (RR) with 95% confidence interval (CI). Nine studies from different provinces/cities were identified according to the predefined inclusion and exclusion criteria. There were a total of 1070 patients with diabetes, out of the 8807 COVID-19 cases. The majority of the cases were derived from Hubei Province. A low degree of heterogeneity in the risk estimates was observed in the included studies. Meta-analysis showed that there was a significant association of preexisting diabetes with disease severity or death. The pooled RR was 2.96 (95% CI: 2.31-3.79; p < 0.001). Sensitivity analysis demonstrated no significant changes in the pooled estimates. Comorbid diabetes was associated with an increased risk of disease severity or death in Chinese COVID-19 patients.
Languageen
PublisherElsevier
SubjectCOVID-19
Comorbidity
Death
Diabetes
Severity
TitleComorbid diabetes and the risk of disease severity or death among 8807 COVID-19 patients in China: A meta-analysis.
TypeArticle
Pagination108346
Volume Number166
ESSN1872-8227
dc.accessType Open Access


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