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AuthorSharifi, Majid
AuthorHasan, Anwarul
AuthorNanakali, Nadir Mustafa Qadir
AuthorSalihi, Abbas
AuthorQadir, Fikry Ali
AuthorMuhammad, Hawzheen A.
AuthorShekha, Mudhir Sabir
AuthorAziz, Falah Mohammad
AuthorAmen, Karwan M.
AuthorNajafi, Farrokh
AuthorYousefi-Manesh, Hasan
AuthorFalahati, Mojtaba
Available date2020-08-23T08:26:42Z
Publication Date2020-12-01
Publication NameScientific Reports
Identifierhttp://dx.doi.org/10.1038/s41598-020-62429-6
CitationSharifi, Majid et. al. Combined chemo-magnetic fieldphotothermal breast cancer therapy based on porous magnetite nanospheres . Scientific RepoRtS. (2020) 10:5925.
ISSN2045-2322
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85083041766&origin=inward
URIhttp://hdl.handle.net/10576/15756
AbstractThe efficacy of different modalities of treating breast cancer is inhibited by several limitations such as off-targeted drug distribution, rapid drug clearance, and drug resistance. To overcome these limitations, we developed Lf-Doxo-PMNSs for combined chemo-MF-PTT. The PMNSs were synthesized by hydrothermal method and their physicochemical properties were examined by FE-SEM, TEM, DLS, TGA, XRD investigations. The cytotoxicity of as-synthesized NPs against 4T1 cells was carried out by MTT and flow cytometry assays. Afterwards, the anti-cancer activities of as-synthesized Lf-Doxo-PMNSs on the tumor status, drug distribution and apoptosis mechanism were evaluated. The anti-cancer assays showed that Lf-Doxo-PMNSs significantly suppressed the cancer cell proliferation and tumor weight by prolonging drug availability and potential drug loading in tumor cells; whereas they showed a minimum cytotoxicity against non-cancerous cells. Likewise, combined chemo-MF-PTT using Lf-Doxo-PMNSs displayed the highest anti-cancer activity followed by combined chemo-PTT and combined chemo-MF therapy based on altering the apoptosis mechanism. Therefore, these results showed that combined chemo-MF-PTT based on Lf-Doxo-PMNSs can be used as a promising therapeutic platform with potential targeted drug delivery and high loading capacity features as well as reducing cancer drug resistance.
Languageen
PublisherNature Research
Subjectchemo-magnetic
field-photothermal
breast cancer
nanospheres
TitleCombined chemo-magnetic field-photothermal breast cancer therapy based on porous magnetite nanospheres
TypeArticle
Issue Number1
Volume Number10
dc.accessType Open Access


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