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The retrospective study of the metabolic patterns of BCG-vaccination in type-2 diabetic individuals in COVID-19 infection

Anwardeen, Najeha R.; Cyprian, Farhan S.; Yassine, Hadi M.; Al-Thani, Asmaa A.; Abdallah, Abdallah M.; ... more authors ... less authors ( Frontiers Media , 2023 , Article)

Background: The cross-protective nature of Bacillus Calmette-Guerin (BCG) vaccine against SARS-CoV-2 virus was previously suggested, however its effect in COVID-19 patients with type 2 diabetes (T2D) and the underlying ...

Assessment of Broadly Reactive Responses in Patients With MERS-CoV Infection and SARS-CoV-2 Vaccination

Zedan, Hadeel T.; Smatti, Maria K.; Thomas, Swapna; Nasrallah, Gheyath K.; Afifi, Nahla M.; ... more authors ... less authors ( American Medical Association , 2023 , Article)

Importance: In the ongoing COVID-19 pandemic, there remain unanswered questions regarding the nature and importance of the humoral immune response against other coronaviruses. Although coinfection of the Middle East ...

Follow up and comparative assessment of IgG, IgA, and neutralizing antibody responses to SARS-CoV-2 between mRNA-vaccinated naïve and unvaccinated naturally infected individuals over 10 months

Salma, Younes; Nicolai, Eleonora; Al-Sadeq, Duaa W.; Younes, Nadin; Al-Dewik, Nader; ... more authors ... less authors ( Elsevier , 2023 , Article)

BackgroundEvidence on the effectiveness of vaccination-induced immunity compared to SARS-CoV-2 natural immunity is warranted to inform vaccination recommendations. AimIn this study, we aimed to conduct a comparative ...

Enhancing the sensitivity of rapid antigen detection test (RADT) of different SARS-CoV-2 variants and lineages using fluorescence-labeled antibodies and a fluorescent meter

Gheyath K., Nasrallah; Ali, Fatma; Younes, Salma; Al Khatib, Heba A.; Al-Thani, Asmaa A.; ... more authors ... less authors ( Elsevier , 2023 , Article)

RT-qPCR is considered the gold standard for diagnosis of COVID-19; however, it is laborious, time-consuming, and expensive. RADTs have evolved recently as relatively inexpensive methods to address these shortcomings, but ...

Population immunity of natural infection, primary-series vaccination, and booster vaccination in Qatar during the COVID-19 pandemic: an observational study

Suelen H., Qassim; Chemaitelly, Hiam; Ayoub, Houssein H.; Coyle, Peter; Tang, Patrick; ... more authors ... less authors ( Elsevier , 2023 , Article)

BackgroundWaning of natural infection protection and vaccine protection highlight the need to evaluate changes in population immunity over time. Population immunity of previous SARS-CoV-2 infection or of COVID-19 vaccination ...

Bivalent mRNA-1273.214 vaccine effectiveness against SARS-CoV-2 omicron XBB* infections

Chemaitelly, Hiam; Ayoub, Houssein H.; AlMukdad, Sawsan; Faust, Jeremy S.; Tang, Patrick; ... more authors ... less authors (2023 , Article)

In October of 2022, Qatar introduced COVID-19 bivalent vaccination for persons ≥ 12 years using the 50-μg mRNA-1273.214 vaccine combining SARS-CoV-2 ancestral and omicron BA.1 strains.1 We estimated this vaccine’s effectiveness ...

Detection of Antinuclear Antibodies Targeting Intracellular Signal Transduction, Metabolism, Apoptotic Processes and Cell Death in Critical COVID-19 Patients

Nasarallah, Gheyath K.; Fakhroo, Aisha D.; Khan, Taushif; Cyprian, Farhan S.; Al Ali, Fatima; ... more authors ... less authors ( Universita Cattolica del Sacro Cuore , 2022 , Article)

Background and Objectives: The heterogeneity of the coronavirus disease of 2019 (COVID-19) lies within its diverse symptoms and severity, ranging from mild to lethal. Acute respiratory distress syndrome (ARDS) is a leading ...

Long-term COVID-19 booster effectiveness by infection history and clinical vulnerability and immune imprinting: a retrospective population-based cohort study

Hiam, Chemaitelly; Ayoub, Houssein H; Tang, Patrick; Coyle, Peter; Yassine, Hadi M; ... more authors ... less authors ( Elsevier , 2023 , Article)

BackgroundLong-term effectiveness of COVID-19 mRNA boosters in populations with different previous infection histories and clinical vulnerability profiles is inadequately understood. We aimed to investigate the effectiveness ...

Comparative analysis of within-host diversity among vaccinated COVID-19 patients infected with different SARS-CoV-2 variants

Hebah A., Al-Khatib; Smatti, Maria K.; Ali, Fatma H.; Zedan, Hadeel T.; Thomas, Swapna; ... more authors ... less authors ( Elsevier , 2022 , Article)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a rapidly evolving RNA virus that mutates within hosts and exists as viral quasispecies. Here, we evaluated the within-host diversity among vaccinated and ...

Turning point in COVID-19 severity and fatality during the pandemic: a national cohort study in Qatar

Chemaitelly, Hiam; Ayoub, Houssein H; Faust, Jeremy Samuel; Coyle, Peter; Tang, Patrick; ... more authors ... less authors ( BMJ Publishing Group , 2023 , Article)

Objective To assess the evolution of COVID-19 severity and fatality in a unique setting that consistently applied, throughout the pandemic, rigorous and standardised criteria for defining severe COVID-19 outcomes. Methods ...

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