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Pre-fusion structure of a human coronavirus spike protein

Kirchdoerfer, Robert N.; Cottrell, Christopher A.; Wang, Nianshuang; Pallesen, Jesper; Yassine, Hadi M.; ... more authors ... less authors ( Nature Publishing Group , 2015 , Article)

HKU1 is a human betacoronavirus that causes mild yet prevalent respiratory disease1, and is related to the zoonotic SARS2 and MERS3 betacoronaviruses, which have high fatality rates and pandemic potential. Cell tropism ...

Diagnostic Efficiency of Three Fully Automated Serology Assays and Their Correlation with a Novel Surrogate Virus Neutralization Test in Symptomatic and Asymptomatic SARS-COV-2 Individuals

Younes, Salma; Al-Jighefee, Hadeel; Shurrab, Farah; Al-Sadeq, Duaa W.; Younes, Nadin; ... more authors ... less authors ( MDPI , 2020 , Article)

Abstract: To support the deployment of serology assays for population screening during the COVID-19 pandemic, we compared the performance of three fully automated SARS-CoV-2 IgG assays: Mindray CL-900i® (target: spike [S] ...

Within-host diversity of SARS-CoV-2 in COVID-19 patients with variable disease severities

Al Khatib, Hebah A.; Benslimane, Fatiha M.; El Bashir, Israa; Al Thani, Asmaa A; Yassine, Hadi M. ( Qatar University Press , 2020 , Poster)

Background: The ongoing pandemic of SARS-COV-2 has already infected more than eight million people worldwide. The majority of COVID-19 patients are either asymptomatic or have mild symptoms. Yet, about 15% of the cases ...

Host genetic variants potentially associated with SARS-CoV-2: A multi-population analysis

Smatti, Maria K.; Al-Sarraj, Yasser; Albagha, Omar; Yassine, Hadi M. ( Qatar University Press , 2020 , Poster)

Background: Clinical outcomes of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) showed enormous inter-individual and inter-population differences, possibly ...

Nanopore Sequencing SARS-CoV-2 genome in Qatar

Benslimane, Fatiha M.; Al Khatib, Hebah; Albatesh, Dana; Al-Jamal, Ola; Boughattas, Sonia; ... more authors ... less authors ( Qatar University Press , 2020 , Poster)

Background: The current pandemic, COVID-19, is cause by an RNA coronavirus that was recently identified as SARS-CoV-2. RNA viruses tend to have a high mutation rate; the rate is around a million times greater than that of ...

Evaluation of reverse transcription-loop-mediated isothermal amplification (RT-LAMP) for detecting SARS-CoV-2 in clinical, environmental and animal samples.

Benslimane, Fatiha M.; Al-Jamal, Ola; Boughattas, Sonia|Al Thani, Asmaa A; Yassine, Hadi M. ( Qatar University Press , 2020 , Poster)

Background: First described 20 years ago by Notomi et al., the loop-mediated isothermal amplification (LAMP) assay is robust, rapid and straightforward, yet retains high sensitivity and specificity. These features have ...

Virtual screening of anti-viral drugs and natural compounds for potential inhibition of the novel SARS-CoV-2 spike receptor-binding domain

Mathew, Shilu M.; Benslimane, Fatiha; Althani, Asmaa A.; Yassine, Hadi M. ( Qatar University Press , 2020 , Poster)

Background: The spike (S) protein of SARS-CoV-2 harbors the receptor-binding domain (RBD) that mediates the virus's entry to host cells. The aim of this study was to identify novel inhibitors that target the RBD domain of ...

Demographic and Clinical Characteristics of Early Travel-Associated COVID-19 Cases

Marei, Reham M.; Emara, Mohamed M.; Elsaied, Omar M.; Nasrallah, Gheyath K.; Chivese, Tawanda; ... more authors ... less authors ( Frontiers Media , 2020 , Article)

© Copyright © 2020 Marei, Emara, Elsaied, Nasrallah, Chivese, Al-Romaihi, Althani, Al Thani, Farag and Yassine. Background: SARS-CoV-2 continues to claim hundreds of thousands of people's lives. It mostly affects the elderly ...

Evaluation of antibody response in symptomatic and asymptomatic covid-19 patients and diagnostic assessment of new IgM/IgG elisa kits

Al-Jighefee, Hadeel T.; Yassine, Hadi M.; Nasrallah, Gheyath K. ( MDPI , 2021 , Article)

© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This study aims to study the immune response and evaluate the performances of four new IgM and five IgG enzyme-linked immunosorbent assay (ELISA) kits for detecting ...

Two prolonged viremic SARS-CoV-2 infections with conserved viral genome for two months

Laith J., Abu-Raddad; Chemaitelly, Hiam; Malek, Joel A.; Ahmed, Ayeda A.; Mohamoud, Yasmin A.; ... more authors ... less authors ( Elsevier , 2021 , Article)

We document two cases of viremic and prolonged active infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) where the viral genome was conserved for two months, but infection was with little or ...