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Virtual screening of anti-viral drugs and natural compounds for potential inhibition of the novel SARS-CoV-2 spike receptor-binding domain

Mathew, Shilu M.; Benslimane, Fatiha; Althani, Asmaa A.; Yassine, Hadi M. ( Qatar University Press , 2020 , Poster)

Background: The spike (S) protein of SARS-CoV-2 harbors the receptor-binding domain (RBD) that mediates the virus's entry to host cells. The aim of this study was to identify novel inhibitors that target the RBD domain of ...

Within-host diversity of SARS-CoV-2 in COVID-19 patients with variable disease severities

Al Khatib, Hebah A.; Benslimane, Fatiha M.; El Bashir, Israa; Al Thani, Asmaa A; Yassine, Hadi M. ( Qatar University Press , 2020 , Poster)

Background: The ongoing pandemic of SARS-COV-2 has already infected more than eight million people worldwide. The majority of COVID-19 patients are either asymptomatic or have mild symptoms. Yet, about 15% of the cases ...

Host genetic variants potentially associated with SARS-CoV-2: A multi-population analysis

Smatti, Maria K.; Al-Sarraj, Yasser; Albagha, Omar; Yassine, Hadi M. ( Qatar University Press , 2020 , Poster)

Background: Clinical outcomes of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) showed enormous inter-individual and inter-population differences, possibly ...

Evaluation of reverse transcription-loop-mediated isothermal amplification (RT-LAMP) for detecting SARS-CoV-2 in clinical, environmental and animal samples.

Benslimane, Fatiha M.; Al-Jamal, Ola; Boughattas, Sonia|Al Thani, Asmaa A; Yassine, Hadi M. ( Qatar University Press , 2020 , Poster)

Background: First described 20 years ago by Notomi et al., the loop-mediated isothermal amplification (LAMP) assay is robust, rapid and straightforward, yet retains high sensitivity and specificity. These features have ...

Nanopore Sequencing SARS-CoV-2 genome in Qatar

Benslimane, Fatiha M.; Al Khatib, Hebah; Albatesh, Dana; Al-Jamal, Ola; Boughattas, Sonia; ... more authors ... less authors ( Qatar University Press , 2020 , Poster)

Background: The current pandemic, COVID-19, is cause by an RNA coronavirus that was recently identified as SARS-CoV-2. RNA viruses tend to have a high mutation rate; the rate is around a million times greater than that of ...

Two prolonged viremic SARS-CoV-2 infections with conserved viral genome for two months

Laith J., Abu-Raddad; Chemaitelly, Hiam; Malek, Joel A.; Ahmed, Ayeda A.; Mohamoud, Yasmin A.; ... more authors ... less authors ( Elsevier , 2021 , Article)

We document two cases of viremic and prolonged active infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) where the viral genome was conserved for two months, but infection was with little or ...

Diagnostic Efficiency of Three Fully Automated Serology Assays and Their Correlation with a Novel Surrogate Virus Neutralization Test in Symptomatic and Asymptomatic SARS-COV-2 Individuals

Younes, Salma; Al-Jighefee, Hadeel; Shurrab, Farah; Al-Sadeq, Duaa W.; Younes, Nadin; ... more authors ... less authors ( MDPI , 2020 , Article)

Abstract: To support the deployment of serology assays for population screening during the COVID-19 pandemic, we compared the performance of three fully automated SARS-CoV-2 IgG assays: Mindray CL-900i® (target: spike [S] ...

Evaluation of antibody response in symptomatic and asymptomatic covid-19 patients and diagnostic assessment of new IgM/IgG elisa kits

Al-Jighefee, Hadeel T.; Yassine, Hadi M.; Nasrallah, Gheyath K. ( MDPI , 2021 , Article)

© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This study aims to study the immune response and evaluate the performances of four new IgM and five IgG enzyme-linked immunosorbent assay (ELISA) kits for detecting ...

Demographic and Clinical Characteristics of Early Travel-Associated COVID-19 Cases

Marei, Reham M.; Emara, Mohamed M.; Elsaied, Omar M.; Nasrallah, Gheyath K.; Chivese, Tawanda; ... more authors ... less authors ( Frontiers Media , 2020 , Article)

© Copyright © 2020 Marei, Emara, Elsaied, Nasrallah, Chivese, Al-Romaihi, Althani, Al Thani, Farag and Yassine. Background: SARS-CoV-2 continues to claim hundreds of thousands of people's lives. It mostly affects the elderly ...

The Spectrum of Antibiotic Prescribing During COVID-19 Pandemic: A Systematic Literature Review

Al-Hadidi, Sara H.; Alhussain, Hashim; Abdel Hadi, Hamad; Johar, Alreem; Yassine, Hadi M.; ... more authors ... less authors ( Mary Ann Liebert , 2021 , Article Review)

Objectives: Over the last decades, there has been a significant increase in antimicrobial prescribing and consumption associated with the development of patients’ adverse events and antimicrobial resistance (AMR) to the ...