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Within-host diversity of SARS-CoV-2 in COVID-19 patients with variable disease severities

Al Khatib, Hebah A.; Benslimane, Fatiha M.; El Bashir, Israa; Al Thani, Asmaa A; Yassine, Hadi M. ( Qatar University Press , 2020 , Poster)

Background: The ongoing pandemic of SARS-COV-2 has already infected more than eight million people worldwide. The majority of COVID-19 patients are either asymptomatic or have mild symptoms. Yet, about 15% of the cases ...

Host genetic variants potentially associated with SARS-CoV-2: A multi-population analysis

Smatti, Maria K.; Al-Sarraj, Yasser; Albagha, Omar; Yassine, Hadi M. ( Qatar University Press , 2020 , Poster)

Background: Clinical outcomes of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) showed enormous inter-individual and inter-population differences, possibly ...

Nanopore Sequencing SARS-CoV-2 genome in Qatar

Benslimane, Fatiha M.; Al Khatib, Hebah; Albatesh, Dana; Al-Jamal, Ola; Boughattas, Sonia; ... more authors ... less authors ( Qatar University Press , 2020 , Poster)

Background: The current pandemic, COVID-19, is cause by an RNA coronavirus that was recently identified as SARS-CoV-2. RNA viruses tend to have a high mutation rate; the rate is around a million times greater than that of ...

Evaluation of reverse transcription-loop-mediated isothermal amplification (RT-LAMP) for detecting SARS-CoV-2 in clinical, environmental and animal samples.

Benslimane, Fatiha M.; Al-Jamal, Ola; Boughattas, Sonia|Al Thani, Asmaa A; Yassine, Hadi M. ( Qatar University Press , 2020 , Poster)

Background: First described 20 years ago by Notomi et al., the loop-mediated isothermal amplification (LAMP) assay is robust, rapid and straightforward, yet retains high sensitivity and specificity. These features have ...

Virtual screening of anti-viral drugs and natural compounds for potential inhibition of the novel SARS-CoV-2 spike receptor-binding domain

Mathew, Shilu M.; Benslimane, Fatiha; Althani, Asmaa A.; Yassine, Hadi M. ( Qatar University Press , 2020 , Poster)

Background: The spike (S) protein of SARS-CoV-2 harbors the receptor-binding domain (RBD) that mediates the virus's entry to host cells. The aim of this study was to identify novel inhibitors that target the RBD domain of ...

Soluble ACE2 and Angiotensin II levels Modulated in Hypertensive COVID-19 Patients treated with different Antihypertension Drugs

Yalcin, Huseyin C.; Elrayess, Mohamed A; Al-Jighefee, Hadeel T; Al-Ruweidi, Mahmoud Khatib A. A.; Almuraikhy, Shamma; ... more authors ... less authors ( Qatar University Press , 2021 , Poster)

Hypertension is a major risk factor and common comorbidity among severe Coronavirus Disease 2019 (COVID-19) patients. Prominent antihypertensive drugs, such as angiotensin-converting-enzyme inhibitors (ACEi) and angiotensin ...