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Challenges in Laboratory Diagnosis of the Novel Coronavirus SARS-CoV-2
(
MDPI
, 2020 , Article)
The recent outbreak of the Coronavirus disease 2019 (COVID-19) has quickly spread worldwide since its discovery in Wuhan city, China in December 2019. A comprehensive strategy, including surveillance, diagnostics, research, ...
Within-host diversity of SARS-CoV-2 in COVID-19 patients with variable disease severities
(
Qatar University Press
, 2020 , Poster)
Background: The ongoing pandemic of SARS-COV-2 has already infected more than eight million people worldwide. The majority of COVID-19 patients are either asymptomatic or have mild symptoms. Yet, about 15% of the cases ...
Host genetic variants potentially associated with SARS-CoV-2: A multi-population analysis
(
Qatar University Press
, 2020 , Poster)
Background: Clinical outcomes of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) showed enormous inter-individual and inter-population differences, possibly ...
Nanopore Sequencing SARS-CoV-2 genome in Qatar
(
Qatar University Press
, 2020 , Poster)
Background: The current pandemic, COVID-19, is cause by an RNA coronavirus that was recently identified as SARS-CoV-2. RNA viruses tend to have a high mutation rate; the rate is around a million times greater than that of ...
Evaluation of reverse transcription-loop-mediated isothermal amplification (RT-LAMP) for detecting SARS-CoV-2 in clinical, environmental and animal samples.
(
Qatar University Press
, 2020 , Poster)
Background: First described 20 years ago by Notomi et al., the loop-mediated isothermal amplification (LAMP) assay is robust, rapid and straightforward, yet retains high sensitivity and specificity. These features have ...
Virtual screening of anti-viral drugs and natural compounds for potential inhibition of the novel SARS-CoV-2 spike receptor-binding domain
(
Qatar University Press
, 2020 , Poster)
Background: The spike (S) protein of SARS-CoV-2 harbors the receptor-binding domain (RBD) that mediates the virus's entry to host cells. The aim of this study was to identify novel inhibitors that target the RBD domain of ...
Seasonality of Respiratory Viral Infections: Will COVID-19 Follow Suit?
(
Frontiers Media
, 2020 , Article Review)
Respiratory viruses, including coronaviruses, are known to have a high incidence of infection during winter, especially in temperate regions. Dry and cold conditions during winter are the major drivers for increased ...
Within-Host Diversity of SARS-CoV-2 in COVID-19 Patients With Variable Disease Severities.
(
Frontiers Media
, 2020 , Article)
The ongoing pandemic of SARS-COV-2 has already infected more than eight million people worldwide. The majority of COVID-19 patients either are asymptomatic or have mild symptoms. Yet, about 15% of the cases experience ...
Host Genetic Variants Potentially Associated With SARS-CoV-2: A Multi-Population Analysis.
(
Frontiers Media
, 2020 , Article)
Clinical outcomes of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) showed enormous inter-individual and inter-population differences, possibly due to host ...
Immune Modulatory Effects of Vitamin D on Viral Infections.
(
MDPI
, 2020 , Article)
Viral infections have been a cause of mortality for several centuries and continue to endanger the lives of many, specifically of the younger population. Vitamin D has long been recognized as a crucial element to the ...