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AuthorZaqout, Sami
AuthorBecker, Lena-Luise
AuthorMustafa, Ayman
AuthorKramer, Nadine
AuthorStrauss, Ulf
AuthorKaindl, Angela M.
Available date2020-10-26T08:49:52Z
Publication Date2020
Publication NameQatar University Annual Research an Exhibition 2020 (quarfe)
CitationZaqout S., Becker L.L., Mustafa A., Krsmer N., Strauss U., Kaindl A.M., "Role of Cdk5rap2 in neocortical inhibition and excitation balance", Qatar University Annual Research Forum and Exhibition (QUARFE 2020), Doha, 2020, https://doi.org/10.29117/quarfe.2020.0117
URIhttps://doi.org/10.29117/quarfe.2020.0117
URIhttp://hdl.handle.net/10576/16701
AbstractAutosomal recessive primary microcephaly type 3 (MCPH3) is characterized by congenital microcephaly and intellectual disability. Further features include hyperactivity and seizures. The disease is caused by biallelic mutations in the Cyclin-dependent kinase 5 regulatory subunit-associated protein 2 gene CDK5RAP2. In the mouse, Cdk5rap2 mutations similarly result in reduced brain size and a strikingly thin neocortex already at early stages of neurogenesis that persists through adulthood. The microcephaly phenotype in MCPH arises from a neural stem cell proliferation defect. Here, we report a novel role for Cdk5rap2 in the regulation of dendritic development and synaptogenesis of neocortical layer 2/3 pyramidal neurons using a combined morphological and electrophysiological approach.
Languageen
PublisherQatar University Press
SubjectCdk5rap2
Microcephaly
Neuronal differentiation
Synaptic transmission
Dendritic morphogenesis
TitleRole of Cdk5rap2 in neocortical inhibition and excitation balance
TypePoster
dc.accessType Open Access


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