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AuthorNagi, Karim
AuthorGupta, Ishita
AuthorAl-Thawadi, Hamda A
AuthorJabeen, Ayesha
AuthorMalki, Mohammed I.
AuthorVranic, Semir
AuthorAl-Moustafa, Ala-Eddin
Available date2020-10-26T08:49:52Z
Publication Date2020
Publication NameQatar University Annual Research an Exhibition 2020 (quarfe)
CitationNagi K., Gupta I., AlThawadi H.A, Jabeen A., Malki M.I., Vranic S., AlMoustafa A.E., "Comparison of co-presence of Epstein-Barr virus and high-risk human papillomaviruses in colorectal cancers in the Middle East Region", Qatar University Annual Research Forum and Exhibition (QUARFE 2020), Doha, 2020, https://doi.org/10.29117/quarfe.2020.0121
URIhttps://doi.org/10.29117/quarfe.2020.0121
URIhttp://hdl.handle.net/10576/16705
AbstractBackground: Several studies have shown the presence of onco viral DNA in colorectal tumor tissues. Viral infection by onco-viruses such as Human papillomaviruses (HPVs) and Epstein-Barr virus (EBV) are well-known to be involved in the onset and/or progression of numerous human carcinomas. Methods: We explored the co-presence of high-risk HPVs and EBV in a cohort of colorectal cancer samples from Lebanon (94) and Syria (102) by PCR, immunohistochemistry and tissue microarray. Results: The results of the study point out that 54% of colorectal cancer cases in Syria are positive for high-risk HPVs, while 30% of the cases in Lebanon are positive for these viruses; the most frequent high-risk HPV types in these populations are 16, 18, 31, 33 and 35. Analysis of LMP1 showed similar results in both populations; 36% of Syrian and 31% of Lebanese samples. Additionally, we report that EBV and high-risk HPVs are co-present in these samples. In Syrian samples, EBV and HPVs are co-present in 16% of the population, however, in the Lebanese samples, 20% of the cases are positive for both EBV and HPVs; their co-presence is associated with high/intermediate grade invasive carcinomas. Conclusion: These data suggest that EBV and high-risk HPVs are co-present in human colorectal cancers where they can cooperate in the progression of these cancers. Nevertheless, further studies are needed to elucidate the role of those oncoviruses in the development of human colorectal carcinomas.
Languageen
PublisherQatar University Press
SubjectHPV
EBV
Colorectal Cancer
Syria
Lebanon
TitleComparison of co-presence of Epstein-Barr virus and high-risk human papillomaviruses in colorectal cancers in the Middle East Region
TypePoster


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