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AuthorRabbani, Naila
AuthorThornalley, Paul John
Available date2020-10-26T08:49:53Z
Publication Date2020
Publication NameQatar University Annual Research an Exhibition 2020 (quarfe)
CitationRabbani N., Thornalley P.J., " Blood biomarkers associated with autism spectrum disorder may provide early diagnosis", Qatar University Annual Research Forum and Exhibition (QUARFE 2020), Doha, 2020, https://doi.org/10.29117/quarfe.2020.0151
URIhttps://doi.org/10.29117/quarfe.2020.0151
URIhttp://hdl.handle.net/10576/16734
AbstractAutism Spectrum Disorders (ASD) are a collection of neuropsychiatric disorders. ASD affects 1 in 87 in Qatar and is expected to increase. The high variability and heterogeneity of the symptoms makes diagnosis of ASD difficult and uncertain, particularly at the early stages of development. If detected early, clinical support can be given to promote optimal development and well-being of children with ASD and even achieve complete remission. The current method of diagnosing ASD is by observations and interviews made by experts in child development to assess child behavior, communication and cognition: the ADOS test. There is often delay in referral for expert diagnosis; delay is typically >18 months in Qatar and >4 years in EU and USA. The diagnostic accuracy is 60 - 70%. Mutations in proteins transporters of amino acids have been linked to some cases of ASD. We hypothesized that levels of amino acids in blood, including amino acids damaged by modification by sugars (glycation), oxidation and nitration may provide novel biomarker for diagnosis of ASD at very young age.
Languageen
PublisherQatar University Press
SubjectAutism
Machine learning
Blood test
TitleBlood biomarkers associated with autism spectrum disorder may provide early diagnosis
TypePoster
dc.accessType Open Access


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