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المؤلفAhmed, Elham
المؤلفKhan, Abdul
المؤلفS.Prabhu, Kirti
المؤلفSiveen, Kodappully
المؤلفNawaz, Zafar
المؤلفZayed, Hatem
المؤلفUddin, Shahab
تاريخ الإتاحة2020-10-26T08:49:54Z
تاريخ النشر2020
اسم المنشورQatar University Annual Research an Exhibition 2020 (quarfe)
الاقتباسAhmed E., Khan A., Prabhu S.K., Siveen K., Nawaz Z., Zayed H., Uddin S., " Sanguinarine mediated anti-tumor activity via targeting JAK/STAT3 pathway in thyroid cancer", Qatar University Annual Research Forum and Exhibition (QUARFE 2020), Doha, 2020, https://doi.org/10.29117/quarfe.2020.0155
معرّف المصادر الموحدhttps://doi.org/10.29117/quarfe.2020.0155
معرّف المصادر الموحدhttp://hdl.handle.net/10576/16738
الملخصSanguinarine (SNG), a natural compound with an array of pharmacological activities, has promising therapeutic potential against a number of pathological conditions, including malignancies. This research aimed to investigate the antiproliferative and anti-cancer potential of SNG against two well characterized papillary thyroid cancer (PTC) cell lines, BCPAP and TPC-1 .In both cell lines , SNG was able to inhibit cell proliferation in time and dose dependent manner. Western blot analysis revealed increased expression of apoptosis and autophagy markers , caspase-3,cleaved caspase-3 , P62, and LC3. SNG modulate its anticancer effect through ROS production, because NAC was able to reverse SNG effect. Interestingly, co-treatment of PTC with SNG and cisplatin amplified anticancer activity. Finally, SNG treatment of PTC spheroid suppressed its growth with downregulation of stemness markers including ALDH2 and SOX2 markers. In conclusion, SNG enhanced the anti cancer activity against PTC cells and the effect is amplified when cisplatin is added.
اللغةen
الناشرQatar University Press
الموضوعSanguinarine
JAK/STAT3 Pathway
Thyroid Cancer
العنوانSanguinarine mediated anti-tumor activity via targeting JAK/STAT3 pathway in thyroid cancer
النوعPoster


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