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المؤلفEssa, Asma
المؤلفAldous, Noura
المؤلفBenslimane, Fatiha
المؤلفYalcin, Huseyin
تاريخ الإتاحة2020-10-26T08:49:56Z
تاريخ النشر2020
اسم المنشورQatar University Annual Research an Exhibition 2020 (quarfe)
الاقتباسEssa A., Aldous N., Benslimane F., Yalcin H., "In Vivo Investigation of Cardiac Benefits of Sodium Glucose Cotransporter Inhibition Using the Zebrafish Model", Qatar University Annual Research Forum and Exhibition (QUARFE 2020), Doha, 2020, https://doi.org/10.29117/quarfe.2020.0199
معرّف المصادر الموحدhttps://doi.org/10.29117/quarfe.2020.0199
معرّف المصادر الموحدhttp://hdl.handle.net/10576/16782
الملخصType 2 diabetes mellitus (T2DM) affects >16% of adults in Qatar. Newly emerging class of antidiabetic drugs focuses on SGLT inhibition were observed to reduce CVDs risks in diabetic patients. Up to date, the mechanism contributing to the CV benefits remains unrevealed. Zebrafish embryos were injected with different morpholinos to knockdown SGLT genes and study their effects on cardiac parameters. SGLT1 inhibition caused the most severe effects on zebrafish embryos with survival rate ~10 %. It also caused tube-like structured heats with edema, affecting significantly the cardiac output and diameter, and increased cardiac markers expressions. Analysis acquired correlates with literature data of SGLT1 predominant expression in heart tissues
اللغةen
الناشرQatar University Press
الموضوعT2DM
CVDs
Zebrafish
العنوانIn Vivo Investigation of Cardiac Benefits of Sodium Glucose Cotransporter Inhibition Using the Zebrafish Model
النوعPoster
dc.accessType Open Access


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