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AuthorBen Halima, Taoufik
AuthorVandavasi, Jaya Kishore
AuthorShkoo, Mohanad
AuthorNewma, Stephen G.
Available date2020-11-26T11:21:09Z
Publication Date2017
Publication NameACS Catalysis
ResourceScopus
URIhttp://dx.doi.org/10.1021/acscatal.7b00245
URIhttp://hdl.handle.net/10576/17107
AbstractA palladium-catalyzed cross-coupling between aryl esters and anilines is reported, enabling access to diverse amides. The reaction takes place via activation of the C-O bond by oxidative addition with a Pd-NHC complex, which enables the use of relatively non-nucleophilic anilines that otherwise require stoichiometric activation with strong bases in order to react. High yields of aromatic, aliphatic, and heterocyclic products are obtained. A range of activated esters are evaluated in the presence and absence of catalyst, demonstrating that the catalytic methodology substantially increases the types of electrophiles that can be utilized for amide bond formation in the absence of harsh bases.
Languageen
PublisherAmerican Chemical Society
Subjectamides
C-N coupling
C-O bond activation
cross-coupling
palladium catalysis
TitleA Cross-Coupling Approach to Amide Bond Formation from Esters
TypeArticle
Pagination2176-2180
Issue Number3
Volume Number7
dc.accessType Abstract Only


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