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Novel 1,5-diphenyl-6-substituted 1H-pyrazolo[3,4-d]pyrimidin-4(5H)-ones induced apoptosis in RKO colon cancer cells
(
Taylor and Francis Ltd
, 2016 , Article)
Novel 1,5-diphenyl-6-substituted-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-ones were synthesized and characterized. All compounds were screened for their anti-proliferative activities in five different cancer cell lines. The results ...
Instrumentation of Flow-Through USP IV Dissolution Apparatus to Assess Poorly Soluble Basic Drug Products: a Technical Note
(
Springer New York LLC
, 2016 , Article)
Supersaturation and precipitation are common limitations encountered especially with poorly soluble basic drugs. The aims of this work were to explore the pattern of dissolution and precipitation of poorly soluble basic ...
COVID-19 infection localization and severity grading from chest X-ray images
(
Elsevier Ltd
, 2021 , Article)
The immense spread of coronavirus disease 2019 (COVID-19) has left healthcare systems incapable to diagnose and test patients at the required rate. Given the effects of COVID-19 on pulmonary tissues, chest radiographic ...
Efficacy of aerosol reduction measures for dental aerosol generating procedures
(
Taylor and Francis Ltd.
, 2022 , Article)
Aerosol particles generated by dental procedures could facilitate the transmission of infectious diseases and contain carcinogen particles. Such particles can penetrate common surgical masks and reach the lungs, leading ...
Detection and severity classification of COVID-19 in CT images using deep learning
(
MDPI
, 2021 , Article)
Detecting COVID-19 at an early stage is essential to reduce the mortality risk of the patients. In this study, a cascaded system is proposed to segment the lung, detect, localize, and quantify COVID-19 infections from ...
Is there truly an increase in risk of cardiovascular and hematological adverse events with vascular endothelial growth factor receptor tyrosine kinase inhibitors?
(
Taylor and Francis Ltd
, 2020 , Article)
Objectives: Recent studies have shown an increase risk of cardiovascular and hematological adverse events associated with vascular endothelial growth factor tyrosine kinase inhibitors (VEGF-TKIs). The authors hypothesize ...
Progressive Operational Perceptrons
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Elsevier B.V.
, 2017 , Article)
There are well-known limitations and drawbacks on the performance and robustness of the feed-forward, fully-connected Artificial Neural Networks (ANNs), or the so-called Multi-Layer Perceptrons (MLPs). In this study we ...
Patient-Specific Seizure Detection Using Nonlinear Dynamics and Nullclines
(
Institute of Electrical and Electronics Engineers Inc.
, 2020 , Article)
Nonlinear dynamics has recently been extensively used to study epilepsy due to the complex nature of the neuronal systems. This study presents a novel method that characterizes the dynamic behavior of pediatric seizure ...
Mortality prediction utilizing blood biomarkers to predict the severity of COVID-19 using machine learning technique
(
MDPI
, 2021 , Article)
Healthcare researchers have been working on mortality prediction for COVID-19 patients with differing levels of severity. A rapid and reliable clinical evaluation of disease intensity will assist in the allocation and ...
Acetylcholinesterase inhibitors and risk of bleeding and acute ischemic events in non-hypertensive Alzheimer's patients
(
John Wiley and Sons Inc
, 2021 , Article)
Introduction
Acetylcholinesterase inhibitors (AChEIs) are commonly used to treat mild to moderate cases of Alzheimer disease (AD). To the best of our knowledge, there has been no study estimating the risk of bleeding and ...