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Now showing items 201-210 of 1026
A Review of the Clinical Pharmacokinetics and Pharmacodynamics of Isavuconazole
(
Springer-Verlag France
, 2018 , Article Review)
Invasive fungal infections are a major cause of morbidity and mortality, especially for immunocompromised patients. Treatment options are few and most are limited by safety and formulation concerns. Isavuconazole is a new ...
A Critical Review of the Current Evidence for Measuring Drug Concentrations of First-Line Agents Used to Treat Tuberculosis in Children
(
Springer International Publishing
, 2016 , Article Review)
Tuberculosis is a leading cause of infectious disease-related morbidity and mortality worldwide. Additionally, treatment is complex with most patients requiring combination therapy of first-line agents for multiple months. ...
Resveratrol-mediated regulation of mitochondria biogenesis-associated pathways in neurodegenerative diseases: molecular insights and potential therapeutic applications.
(
Bentham Science Publisher
, 2022 , Article Review)
Neurodegenerative disorders include neurological conditions that affect nerve cells, causing the progressive loss of their functions and ultimately leading to loss of mobility, coordination, and mental functioning. The ...
Metformin in pregnancy to avert gestational diabetes in women at high risk: Meta-analysis of randomized controlled trials.
(
Wiley
, 2019 , Article Review)
Previous randomized and observational studies on the efficacy of metformin in pregnancy to reduce incident gestational diabetes mellitus (GDM) in women at high risk (obesity, polycystic ovary syndrome [PCOS], or pregestational ...
Empowering Technology Enabled Care Using IoT and Smart Devices: A Review
(
Institute of Electrical and Electronics Engineers Inc.
, 2018 , Article Review)
Designing power aware wearable devices is the main key in building compact size autonomous smart devices to successfully connect health Internet of things solutions. With their ability to perform tasks ranging from simple ...
Effects of acute and chronic exercise on immunological parameters in the elderly aged: Can physical activity counteract the effects of aging?
(
Frontiers Media S.A.
, 2018 , Article Review)
Immunosenescence is characterized by deterioration of the immune system caused by aging which induces changes to innate and adaptive immunity. Immunosenescence affects function and phenotype of immune cells, such as ...
A Systematic Scoping Review of the State of Pharmacovigilance and Governance in the MENA Region: Challenges and Opportunities
(
Springer International Publishing
, 2017 , Article Review)
Introduction
Pharmacovigilance (PV) systems around the world vary in capacity and maturity. Many factors can influence PV.
Objectives
This systematic scoping review aims to explore the opportunities for effective PV ...
Region-specific Exercises vs General Exercises in the Management of Spinal and Peripheral Musculoskeletal Disorders: A Systematic Review With Meta-analyses of Randomized Controlled Trials
(
W.B. Saunders
, 2021 , Article Review)
Objective: To compare the efficacy of region-specific exercises to general exercises approaches for adults with spinal or peripheral musculoskeletal disorders (MSKDs). Data Sources: Electronic searches were conducted up ...
DNA-based influenza vaccines as immunoprophylactic agents toward universality
(
Future Medicine Ltd.
, 2016 , Article Review)
Influenza is an illness of global public health concern. Influenza viruses have been responsible for several pandemics affecting humans. Current influenza vaccines have proved satisfactory safety; however, they have ...
The role and mechanism of action of sperm PLC-zeta in mammalian fertilisation
(
Portland Press Ltd
, 2017 , Article Review)
At mammalian fertilisation, the fundamental stimulus that triggers oocyte (egg) activation and initiation of early embryonic development is an acute rise of the intracellular-free calcium (Ca2+) concentration inside the ...