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AuthorNayla Cristina, do Vale Moreira
AuthorCeriello, Antonio
AuthorBasit, Abdul
AuthorBalde, Naby
AuthorMohan, V.
AuthorGupta, Ritesh
AuthorMisra, Anoop
AuthorBhowmik, Bishwajit
AuthorLee, Moon K.
AuthorZuo, Hui
AuthorShi, Zumin
AuthorWang, Youfa
AuthorMontenegro, Renan M.
AuthorFernandes, Virgínia Oliveira
AuthorColagiuri, Stephen
AuthorBoulton, Andrew J.M.
AuthorHussain, Akhtar
Available date2021-06-13T06:19:27Z
Publication Date2021-05-31
Publication NameDiabetes Research and Clinical Practice
Identifierhttp://dx.doi.org/10.1016/j.diabres.2021.108823
Citationdo Vale Moreira NC, Ceriello A, Basit A, Balde N, Mohan V, Gupta R, Misra A, Bhowmik B, Lee MK, Zuo H, Shi Z, Wang Y, Montenegro RM, Fernandes VO, Colagiuri S, Boulton AJM, Hussain A. Race/ethnicity and challenges for optimal insulin therapy. Diabetes Res Clin Pract. 2021 Apr 20;175:108823. doi: 10.1016/j.diabres.2021.108823.
ISSN01688227
URIhttps://www.sciencedirect.com/science/article/pii/S0168822721001820
URIhttp://hdl.handle.net/10576/20601
AbstractAimsWe aimed to review insulin dosing recommendations, insulin regulation and its determinants, glycaemic response to carbohydrates, and the efficacy and safety of insulin therapy in different races/ethnicities. MethodsWe searched for articles in PubMed and Google Scholar databases up to 31 March 2021, with the following keywords: “ethnicity”, “diabetes”, “insulin”, “history of insulin”, “insulin therapy”, “food/rice”, “carbohydrate intake”, “insulin resistance”, “BMI”, “insulin dosing”, “insulin sensitivity”, “insulin response”, “glycaemic index”, “glycaemic response”, “efficacy and safety”, with interposition of the Boolean operator “AND”.In addition, we reviewed the reference lists of the articles found. ResultsThe differential effect of race/ethnicity has not yet been considered in current insulin therapy guidelines. Nevertheless, body size and composition, body mass index, fat distribution, diet, storage, and energy expenditure vary significantly across populations. Further, insulin sensitivity, insulin response, and glycaemicresponse to carbohydrates differ by ethnicity. These disparities may lead to different insulin requirements, adversely impacting the efficacy and safety of insulin therapy among ethnic groups. ConclusionsRace/ethnicity affects glucose metabolism and insulin regulation.Until now, international guidelines addressing racial/ethnic-specific clinical recommendations are limited. Comprehensive updated insulin therapy guidelines by ethnicity are urgently needed.
Languageen
PublisherElsevier
SubjectRace
Ethnicity
Diabetes
Insulin sensitivity
Insulin resistance
Insulin therapy
TitleRace/ethnicity and challenges for optimal insulin therapy
TypeArticle
Volume Number175
Open Access user License http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.accessType Open Access


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