تصفح Academic حسب المؤلف "Da'as, Sahar"
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AEO-7 surfactant is “super toxic” and induces severe cardiac, liver and locomotion damage in zebrafish embryos
Al-Asmakh, Maha; Majdalawieh, Amin F.; Abdullah, Aboubakr M.; Younes, Nadin; Da’as, Sahar I.; Radwan, A. Bahgat; Sliem, Mostafa H.; Ech-Cherif, Houria; Pintus, Gianfranco; Nasrallah, Gheyath K.... more authors ... less authors ( SpringerOpen , 2020 , Article)© 2020, The Author(s). Background: Fatty alcohol polyoxyethylene ether-7 (AEO-7), a non-ionic surfactant, has recently been receiving extensive attention from the ocean pipeline industry for its ability to inhibit corrosion. ... -
Arrhythmogenic calmodulin E105A mutation alters cardiac RyR2 regulation leading to cardiac dysfunction in zebrafish
Da'as, Sahar I; Thanassoulas, Angelos; Calver, Brian L; Beck, Konrad; Salem, Rola; Saleh, Alaaeldin; Kontogianni, Iris; Al-Maraghi, Ali; Nasrallah, Gheyath K; Safieh-Garabedian, Bared; Toft, Egon; Nounesis, George; Lai, F Anthony; Nomikos, Michail... more authors ... less authors ( Wiley , 2019 , Article)Calmodulin (CaM) is a universal calcium (Ca )-binding messenger that regulates many vital cellular events. In cardiac muscle, CaM associates with ryanodine receptor 2 (RyR2) and regulates excitation-contraction coupling. ... -
Functional characterization of human myosin-binding protein C3 variants associated with hypertrophic cardiomyopathy reveals exon-specific cardiac phenotypes in zebrafish model
Da'as, Sahar I.; Yalcin, Huseyin C.; Nasrallah, Gheyath K.; Mohamed, Iman A.; Nomikos, Michail; Yacoub, Magdi H.; Fakhro, Khalid A.... more authors ... less authors ( Wiley , 2020 , Article)© 2020 Wiley Periodicals, Inc. Myosin-binding protein C 3 (MYBPC3) variants are the most common cause of hypertrophic cardiomyopathy (HCM). HCM is a complex cardiac disorder due to its significant genetic and clinical ... -
JC-10 probe as a novel method for analyzing the mitochondrial membrane potential and cell stress in whole zebrafish embryos
Younes, Nadin; Alsahan, Bana S.; Al-Mesaifr, Asmaa J.; Da'as, Sahar I.; Pintus, Gianfranco; Majdalawieh, Amin F.; Nasrallah, Gheyath K.... more authors ... less authors ( Oxford University Press , 2021 , Article)Background: A sensitive method to investigate cellular stress and cytotoxicity is based on measuring mitochondrial membrane potential. Recently, JC-10, was developed to measure mitochondrial membrane potential in vitro and ... -
Organ-specific toxicity evaluation of stearamidopropyl dimethylamine (SAPDMA) surfactant using zebrafish embryos
Al-Jamal, Ola; Al-Jighefee, Hadeel; Younes, Nadin; Abdin, Roba; Al-Asmakh, Maha A.; Radwan, A. Bahgat; Sliem, Mostafa H.; Majdalawieh, Amin F.; Pintus, Gianfranco; Yassine, Hadi M.; Abdullah, Aboubakr M.; Da'as, Sahar I.; Nasrallah, Gheyath K.... more authors ... less authors ( Elsevier , 2020 , Article)Surfactants are widely used in the industry of detergents, household products, and cosmetics. SAPDMA is a cationic surfactant that is used mostly in cosmetics, conditioning agents and has recently gained attention as a ... -
Using Zebrafish for Investigating the Molecular Mechanisms of Drug-Induced Cardiotoxicity
zakaria, zain z.; benslimane, fatiha m.; nasrallah, gheyath k.; shurbaji, samar; younes, nadin n.; Mraiche, Fatima; Da’as, Sahar I.; yalcin, huseyin c.... more authors ... less authors ( Hindawi Publishing Corporation , 2018 , Article)Over the last decade, the zebrafish (Danio rerio) has emerged as amodel organismfor cardiovascular research.Zebrafish have several advantages over mammalian models. For instance, the experimental cost of using zebrafish ...