تصفح Academic حسب المؤلف "Vaikath, Nishant N."
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Novel engineered nanobodies specific for N-terminal region of alpha-synuclein recognize Lewy-body pathology and inhibit in-vitro seeded aggregation and toxicity.
Hmila, Issam; Vaikath, Nishant N; Majbour, Nour K; Erskine, Daniel; Sudhakaran, Indulekha P; Gupta, Vijay; Ghanem, Simona S; Islam, Zeyaul; Emara, Mohamed M; Abdesselem, Houari B; Kolatkar, Prasanna R; Achappa, Devaya K; Vinardell, Tatiana; El-Agnaf, Omar M A... more authors ... less authors ( FEBS PRESS , 2022 , Article)Nanobodies (Nbs), the single-domain antigen-binding fragments of dromedary heavy-chain antibodies (HCAb), are excellent candidates as therapeutic and diagnostic tools in synucleinopathies because of their small size, ... -
Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson’s disease
Majbour, Nour K.; Vaikath, Nishant N.; van Dijk, Karin D.; Ardah, Mustafa T.; Varghese, Shiji; Vesterager, Louise B.; Montezinho, Liliana P.; Poole, Stephen; Safieh-Garabedian, Bared; Tokuda, Takahiko; Teunissen, Charlotte E.; Berendse, Henk W.; van de Berg, Wilma D. J.; El-Agnaf, Omar M. A.... more authors ... less authors ( BioMed Central , 2016 , Article)Background Despite decades of intensive research, to date, there is no accepted diagnosis for Parkinson’s disease (PD) based on biochemical analysis of blood or CSF. However, neurodegeneration in the brains of PD patients ...