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Now showing items 9541-9560 of 25460
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Genetic variations influence brain changes in patients with attention-deficit hyperactivity disorder
( Springer Nature , 2021 , Article Review)Attention-deficit hyperactivity disorder (ADHD) is a neurological and neurodevelopmental childhood-onset disorder characterized by a persistent pattern of inattentiveness, impulsiveness, restlessness, and hyperactivity. ... -
Genetically unmatched human iPSC and ESC exhibit equivalent gene expression and neuronal differentiation potential.
( Nature Publishing Group , 2017 , Article)The potential uniformity between differentiation and therapeutic potential of human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) remains debatable. We studied the gene expression profiles, ... -
Genetics of glutamate and its receptors in autism spectrum disorder
( Springer Nature , 2022 , Article Review)Autism spectrum disorder (ASD) is a neurodevelopmental impairment characterized by deficits in social interaction skills, impaired communication, and repetitive and restricted behaviors that are thought to be due to altered ... -
Genetics of structural and functional brain changes in autism spectrum disorder.
( Springer Nature , 2020 , Article Review)Autism spectrum disorder (ASD) is a neurological and developmental disorder characterized by social impairment and restricted interactive and communicative behaviors. It may occur as an isolated disorder or in the context ... -
Genome Editing Technology: A New Frontier for the Treatment and Prevention of Cardiovascular Diseases
( Elsevier , 2023 , Article Review)Over the past 2 decades, genome-editing technique has proven to be a robust editing method that revolutionizes the field of biomedicine. At the genetic level, it can be efficiently utilized to generate various disease-resistance ... -
Genome Mining of Secreted Effectors of Fusarium Oxysporum, Fusarium Solani and Rhizectonia Solani
( Hamad bin Khalifa University Press (HBKU Press) , 2016 , Conference Paper)Introduction: Of the various devastating diseases triggered by necrotrophic fungi, the diseases caused by following fungi Fusarium oxysporum, Fusarium solani and Rhizectonia solani are of particular economic significance ... -
Genome-Wide Association Study (Gwas) To Uncover Genetic Risk Factors Associated With Low Bone Mineral Density And Osteoporosis In Qatar Population
(2019 , Master Thesis)Osteoporosis is an increasingly prevalent, global health burden characterized by low bone mineral density (BMD) and increased fracture risk. Despite the serious consequences of osteoporosis and the significant impact it ... -
Genome-wide association study identifies a novel association between a cardiovascular gene polymorphism and superior athletic performance
( Qatar University Press , 2020 , Poster)Background: Research into the genetic predisposition to superior athletic performance has been a hindered by the underpowered studies and the small effect size of identified genetic variants. The aims of this study were ... -
Genome-wide association study identifies several loci for HEV seropositivity
( Elsevier , 2023 , Article)Hepatitis E viral (HEV) infection imposes a heavy global health burden. The variability in the prevalence of serological markers of HEV infection between different ethnic groups proposes a host genetic influence. Here, we ... -
Genome-Wide Association Study Reveals a Novel Association Between MYBPC3 Gene Polymorphism, Endurance Athlete Status, Aerobic Capacity and Steroid Metabolism.
( Frontiers Media , 2020 , Article)The genetic predisposition to elite athletic performance has been a controversial subject due to the underpowered studies and the small effect size of identified genetic variants. The aims of this study were to investigate ... -
Genome-wide polygenic score, clinical risk factors, and long-term trajectories of coronary artery disease
( American Heart Association , 2020 , Article)OBJECTIVE: To determine the relationship of a genome-wide polygenic score for coronary artery disease (GPSCAD) with lifetime trajectories of CAD risk, directly compare its predictive capacity to traditional risk factors, ... -
Genomewide association analysis of warfarin dose requirements in Middle Eastern and North African populations
( Wiley-Blackwell , 2022 , Article)To date, there has been no genomewide association study (GWAS) from the Middle East and North African (MENA) region to identify genetic variants associated with warfarin dose variability using this approach. In this study, ... -
Genomic Alterations, Gene Expression Profiles and Functional Enrichment of Normal-Karyotype Acute Myeloid Leukaemia Based on Targeted Next-Generation Sequencing
( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)Characterising genomic variants is paramount in understanding the pathogenesis and heterogeneity of normal-karyotype acute myeloid leukaemia (AML-NK). In this study, clinically significant genomic biomarkers were ascertained ... -
Genomic and Bioinformatics Approaches for Analysis of Genes Associated With Cancer Risks Following Exposure to Tobacco Smoking
( Frontiers Media S.A. , 2018 , Article Review)Cancer is a significant health problem in the Middle East and global population. It is well established that there is a direct link between tobacco smoking and cancer, which will continue to pose a significant threat to ... -
Genomic Characterization and Annotation of Two Novel Bacteriophages Isolated from a Wastewater Treatment Plant in Qatar
( American Society for Microbiology , 2022 , Article)We report the genome sequences of Escherichia phage C600M2 (length, 88,162 bp; G1C content, 38.98%) and Escherichia phage CL1 (length, 87,820 bp; G1C content, 41.32%), which were isolated from a wastewater treatment plant ... -
Genomic insights and advanced machine learning: characterizing autism spectrum disorder biomarkers and genetic interactions
( Springer , 2024 , Article)Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by altered brain connectivity and function. In this study, we employed advanced bioinformatics and explainable AI to analyze gene ... -
Genomic landscape of prominent XDR Acinetobacter clonal complexes from Dhaka, Bangladesh
( BioMed Central Ltd , 2022 , Article)Background: Acinetobacter calcoaceticus-A. baumannii (ACB) complex pathogens are known for their prevalence in nosocomial infections and extensive antimicrobial resistance (AMR) capabilities. While genomic studies worldwide ... -
Genotoxic impact of long-term cigarette and waterpipe smoking on DNA damage and oxidative stress in healthy subjects
( Taylor and Francis Ltd , 2019 , Article)Although a plethora of studies have examined tobacco smoke-cancer disease association, the involvement of cellular genetic toxicity remains unclear. Therefore, the present study provides molecular evidence for a pathway ... -
Genotoxicity and Embryotoxicity of the Insecticide Primicid in Chick Embryo
( Qatar University , 2000 , Article)Growing chick embryos were treated with primicid to examine the cytogenetic and embryotoxic effects of this insecticide. For the cytogenetic assay, eggs were injected through the air chamber with primicid at a concentration ... -
Genotype-phenotype correlation in 18 Egyptian patients with glutaric acidemia type I
( Springer US , 2017 , Article)Glutaric acidemia I (GAI) is an autosomal recessive metabolic disease caused by a deficiency of glutaryl-CoA dehydrogenase enzyme (GCDH). Patients with GAI are characterized by macrocephaly, acute encephalitis-like crises, ...