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Now showing items 11871-11880 of 11901
THE EFFECT OF OBESITY ON RIVAROXABAN PHARMACOKINETICS AND PHARMACODYNAMICS
(2024 , Dissertation)
Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is a prevalent condition that is associated with high rates of morbidity and mortality worldwide. Similarly, atrial fibrillation ...
INVESTIGATING THE ROLE OF THE ARYL HYDROCARBON RECEPTOR AND BCL-2 FAMILY PROTEINS IN OVARIAN CANCER STEM CELLS DEVELOPMENT AND CHEMORESISTANCE
(2024 , Dissertation)
Gynecological malignancies are a severe threat to female health. Ovarian Cancer (OC),
the most lethal gynecological malignancy, is clinically presented with chemoresistance
and a higher relapse rate. This could be endorsed ...
PRENATAL WHOLE EXOME SEQUENCING OF FETAL SONOGRAPHIC ABNORMALITIES IN QATAR: DIAGNOSTIC YIELD AND GENETIC FINDINGS
(2024 , Professional Masters Project)
Background: Fetal sonographic abnormalities at birth is estimated to be 2-3% of the global prevalence and are responsible for approximately 17%-42% of all perinatal deaths. Prenatal karyotype (KT) and chromosomal microarray ...
ANALYSIS OF MUTATIONS USING ANCIENT DNA GENOMES TO UNDERSTAND PATHOGENIC EMERGENCE AND DISEASE EVOLUTION
(2024 , Master Thesis)
Paleogenomics, the study of ancient DNA, has revolutionized our comprehension of human history by providing access to genomic data spanning hundreds of thousands of years. High-throughput sequencing methods have enabled ...
GENETIC CAUSES OF CARDIAC CHANNELOPATHIES IN QATAR: TOWARD RISK STRATIFICATION AND MANAGEMENT STRATEGIES OF DISEASE
(2024 , Professional Masters Project)
Background: Cardiac channelopathies are inherited disorders caused by pathogenic variants in genes encoding cardiac ion channels, disrupting ion currents, and leading to heart arrhythmias without structural heart defects. ...
UNRAVELING THE MICROBIOME DIVERSITY AND DYNAMICS IN DIFFERENT SAMPLE TYPES DURING CORONAVIRUS INFECTIONS
(2024 , Master Thesis)
Background: Mucosal immunity and gut microbiome influence respiratory diseases like those caused by coronaviruses (HCoV). This study explores the relationship between HCoV infection and the respiratory and gut microbiome. ...
QATAR NATIONAL EXPANDED METABOLIC NEWBORN SCREENING PROGRAM: INCIDENCE AND OUTCOMES
(2024 , Professional Masters Project)
Background: Newborn screening (NBS) is an essential public health strategy that aims to detect and diagnose inborn errors of metabolism (IEMs) in infants shortly after birth, typically through a minimally invasive heel ...
ADVANCED 3D-PRINTED MULTILAYER POROUS MEMBRANES FOR EFFECTIVE WASTEWATER TREATMENT
(2024 , Master Thesis)
Wastewater treatment plays a crucial role in safeguarding public health and environmental sustainability by removing pollutants and contaminants from water sources. Membrane-based filtration technologies have emerged as ...
TRANSLATION AND ADAPTATION OF THE GENETIC COUNSELING OUTCOME SCALE (GCOS-24) FOR THE EVALUATION OF GENETIC COUNSELING SERVICES IN QATAR.
(2024 , Professional Masters Project)
Background. The Genetic Counseling Outcome Scale (GCOS-24), introduced in the United Kingdom (UK) in 2011, is a theory-driven patient-reported outcome measure (PROM) developed for evaluating clinical genetics services. ...
INVESTIGATING THE MOLECULAR MECHANISMS OF SHEAR STRESS INDUCED ENDOTHELIAL DYSFUNCTION AND PROGRESSION OF ATHEROSCLEROSIS
(2024 , Dissertation)
Background: Atherosclerotic vascular disease, such as coronary artery disease (CAD) and ischemic stroke is the leading cause of mortality and disability worldwide. Therefore, understanding the mechanisms underlying ...