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Determining the role of missense mutations in the POU domain of HNF1A that reduce the DNA-binding affinity: A computational approach
(
Plos One
, 2017 , Article)
Maturity-onset diabetes of the young type 3 (MODY3) is a non-ketotic form of diabetes associated with poor insulin secretion. Over the past years, several studies have reported the association of missense mutations in the ...
Specific bioactive compounds in ginger and apple alleviate hyperglycemia in mice with high fat diet-induced obesity via Nrf2 mediated pathway
(
Elsevier
, 2017 , Article)
Prolonged hyperglycemia activates the formation of advanced glycation end-products (AGEs). Major
dicarbonyl compounds such as methylglyoxal or glyoxal are found to be the main precursors of AGEs
and N(e)-(carboxymethyl)lysine ...
Aldose Reductase as a Drug Target for Treatment of Diabetic Nephropathy: Promises and Challenges.
(
Bentham Science Publishers
, 2017 , Article)
Diabetic nephropathy (DN) is one of the most serious microvascular complications of diabetes mellitus and the leading cause of end stage renal disease. One of the key pathways activated in DN is the polyol pathway, in which ...
Effect of foreign direct investment on domestic enterprises in the gulf countries
(
The Institute for Business and Finance Research (IBFR)
, 2017 , Article)
This study examines the impact of foreign direct investment (FDI) on privately owned domestic firms in the Gulf oil producing countries. It provides its analysis through an examination of the role of FDI in sustainable ...
Mesenchymal Stem Cells in the Treatment of Traumatic Brain Injury.
(
Frontiers Media
, 2017 , Article)
Traumatic brain injury (TBI) is characterized by a disruption in the normal function of the brain due to an injury following a trauma, which can potentially cause severe physical, cognitive, and emotional impairment. The ...
Renoprotective Effects of Aldose Reductase Inhibitor Epalrestat against High Glucose-Induced Cellular Injury
(
Hindawi
, 2017 , Article)
Diabetic nephropathy (DN) is the leading cause of end stage renal disease worldwide. Increased glucose flux into the aldose reductase (AR) pathway during diabetes was reported to exert deleterious effects on the kidney. ...
Genetically unmatched human iPSC and ESC exhibit equivalent gene expression and neuronal differentiation potential.
(
Nature Publishing Group
, 2017 , Article)
The potential uniformity between differentiation and therapeutic potential of human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) remains debatable. We studied the gene expression profiles, ...
Relationship between Inward Investment and Productivity in Oman
(
OMICS International
, 2017 , Article)
This study explores how the peculiarity of economic structure and institutions affect the relationship between inward
investment and productivity of domestic firms in Oman. It provides its analysis through an examination ...
Effective and stable FeNi@ N-doped graphene counter electrode for enhanced performance dye sensitized solar cells
(
Elsevier
, 2017 , Article)
N-doped FeNi@graphene is introduced as effective and stable non-precious counter electrode for the dye sensitized solar cells. After preparation of graphene oxide using the chemical route, the obtained product has been ...
Pertussis toxin IgA testing over-diagnoses recent pertussis infection
(
Elsevier
, 2017 , Article)
The importance of pertussis toxin (PT) IgA testing in the diagnosis of recent pertussis infection remains unclear. The contribution of PT IgA to the diagnosis of recent pertussis was reviewed in two separate analyses. ...