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Novel Isosteviol Derivatives Induced Apoptosis In Human Lung Cancer
(
Hamad bin Khalifa University Press (HBKU Press)
, 2014 , Conference Paper)
Background. Cancer metastasis is the major cause of cancer death. We previously reported novel isosteviols derivatives which induced cytotoxicity in lung cancer cells. The understanding of mechanisms which regulate lung ...
The spectrum of chromosomal translocations in the Arab world: ethnic-specific chromosomal translocations and their relevance to diseases
(
Springer Science and Business Media Deutschland GmbH
, 2022 , Article Review)
Chromosomal translocations (CTs) are the most common type of structural chromosomal abnormalities in humans. CTs have been reported in several studies in the Arab world, but the frequency and spectrum of these translocations ...
Bioengineered microfluidic blood-brain barrier models in oncology research
(
Neoplasia Press, Inc.
, 2021 , Article)
Metastasis is the major reason for most brain tumors with up to a 50% chance of occurrence in patients with other types of malignancies. Brain metastasis occurs if cancer cells succeed to cross the ?blood-brain barrier? ...
Erratum: Author Correction: Signatures of co-deregulated genes and their transcriptional regulators in colorectal cancer (NPJ systems biology and applications (2020) 6 1 (23))
(
NLM (Medline)
, 2020 , Other)
In the original version of this Article, the wrong images were supplied for Figures 7 and 10. This has now been corrected in both the HTML and PDF versions of the Article.
Development of A Novel Liposomal Formulation of a Pyridine Chalcone Analogue for HER-2 Positive Breast Cancer
(2024 , Master Thesis)
Breast cancer is the most prevalent cancer in women and the fifth leading cause of death due to cancer worldwide. Human epidermal growth factor receptor-2 (HER-2) is an oncoprotein that is overexpressed in 25-30% of breast ...
Role of animal research in human malignancies
(
Elsevier
, 2019 , Book chapter)
Animal models are the central backbone in relation to providing the safety information of xenobiotics, the nature of chemicals present in the environment, and understanding the developmental process in disease pathogenesis ...
Epigenetic inhibitors and their role in cancer therapy
(
Elsevier
, 2023 , Article)
Epigenetic modifications to DNA are crucial for normal cellular and biological functioning. DNA methylation, histone modifications, and chromatin remodeling are the most common epigenetic mechanisms. These changes are ...
Curcumin-mediated degradation of S-phase kinase protein 2 induces cytotoxic effects in human papillomavirus-positive and negative squamous carcinoma cells
(
Frontiers Media S.A.
, 2018 , Article)
S-phase kinase-associated protein2 (Skp2), a proto-oncoprotein, plays an important role in development and progression of human malignancies. Skp2 is frequently overexpressed in many human malignancies. It targets cell ...
The Dual Specificity Role of Transcription Factor FOXO in Type 2-diabetes and Cancer
(
Bentham Science Publishers
, 2018 , Article Review)
The FOXO (Forkhead box O) transcription factors are implicated in several signaling pathways and play a vital role in various cellular and physiological processes include for instance, ROS (reactive oxygen species) response, ...
Co-Presence and Cooperation of High-Risk Human Papillomaviruses and Epstein-Barr Virus in Colorectal Cancer
(2024 , Dissertation)
The Human Papillomavirus (HPV) and Epstein-Barr Virus (EBV) are potent oncoviruses involved in the pathogenesis of various cancers like colorectal cancer. Further the cooperation between high risk (HR) types of HPV as well ...