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Bioinformatic analysis of human opn3 alternative promoters associated with cancer
(
Natural Sciences Publishing Co.
, 2016 , Article)
In this bioinformatics study we analyzed the functional motifs and structural features of regulatory regions of OPN3, a member of the guanine nucleotide-binding protein (G protein)-coupled receptor super-family, which is ...
Anticancer activity of Neosetophomone B, A Fungal Secondary Metabolite, against Hematological Malignancies
(
Qatar University Press
, 2021 , Poster)
Cancer is one of the most life threatening diseases, causing nearly 13% death in the worldwide. Leukemia, cancer of the hematopoetic cells is the main cause of cancer death in adults and children. Therapeutic agents used ...
Serum vitamin D concentrations are non-linearly related to breast cancer risk in postmenopausal women
(
Qatar University Press
, 2021 , Poster)
Background: Post-menopausal women are at high risk for breast cancer. The association between serum 25-hydroxyvitamin D [25(OH)D] concentration and breast cancer in post-menopausal women is not well understood. Objectives: ...
Role of NAD+ in regulating cellular and metabolic signaling pathways
(
Elsevier
, 2021 , Article Review)
BackgroundNicotinamide adenine dinucleotide (NAD+), a critical coenzyme present in every living cell, is involved in a myriad of metabolic processes associated with cellular bioenergetics. For this reason, NAD+ is often ...
miRNAs as novel immunoregulators in cancer
(
Elsevier
, 2021 , Article Review)
The immune system is a well-known vital regulator of tumor growth, and one of the main hallmarks of cancer is evading the immune system. Immune system deregulation can lead to immune surveillance evasion, sustained cancer ...
3D Bioprinted cancer models: Revolutionizing personalized cancer therapy
(
Neoplasia Press, Inc.
, 2021 , Article)
After cardiovascular disease, cancer is the leading cause of death worldwide with devastating health and economic consequences, particularly in developing countries. Inter-patient variations in anti-cancer drug responses ...
Bioengineered microfluidic blood-brain barrier models in oncology research
(
Neoplasia Press, Inc.
, 2021 , Article)
Metastasis is the major reason for most brain tumors with up to a 50% chance of occurrence in patients with other types of malignancies. Brain metastasis occurs if cancer cells succeed to cross the ?blood-brain barrier? ...
Chemically modified mRNA beyond COVID-19: Potential preventive and therapeutic applications for targeting chronic diseases
(
Elsevier
, 2022 , Article Review)
Chemically modified mRNA represents a unique, efficient, and straightforward approach to produce a class of biopharmaceutical agents. It has been already approved as a vaccination-based method for targeting SARS-CoV-2 ...
Novel Isosteviol Derivatives Induced Apoptosis In Human Lung Cancer
(
Hamad bin Khalifa University Press (HBKU Press)
, 2014 , Conference Paper)
Background. Cancer metastasis is the major cause of cancer death. We previously reported novel isosteviols derivatives which induced cytotoxicity in lung cancer cells. The understanding of mechanisms which regulate lung ...
Integrative ontology and pathway-based approach identifies distinct molecular signatures in transcriptomes of esophageal squamous cell carcinoma
(
Elsevier
, 2022 , Book chapter)
Esophageal squamous cell carcinoma (ESCC) remains a serious concern globally due to many factors that including late diagnosis, lack of an ideal biomarker for diagnosis and prognosis, and high rate of mortality. In this ...