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Evolving strategies and application of proteins and peptide therapeutics in cancer treatment
(
Elsevier
, 2023 , Article Review)
Several proteins and peptides have therapeutic potential and can be used for cancer therapy. By binding to cell surface receptors and other indicators uniquely linked with or overexpressed on tumors compared to healthy ...
The Implication of Mechanistic Approaches and the Role of the Microbiome in Polycystic Ovary Syndrome (PCOS): A Review
(
Multidisciplinary Digital Publishing Institute (MDPI)
, 2023 , Article)
As a complex endocrine and metabolic condition, polycystic ovarian syndrome (PCOS) affects women’s reproductive health. These common symptoms include hirsutism, hyperandrogenism, ovulatory dysfunction, irregular menstruation, ...
Exome sequence analysis of rare frequency variants in Late-Onset Alzheimer Disease
(
Springer Nature
, 2023 , Article)
Alzheimer disease (AD) is a leading cause of dementia in elderly patients who continue to live between 3 and 11 years of diagnosis. A steep rise in AD incidents is observed in the elderly population in East-Asian countries. ...
Association of single nucleotide polymorphisms with dyslipidemia and risk of metabolic disorders in the State of Qatar
(
Wiley-Blackwell
, 2023 , Article)
Background: Dyslipidemia is recognized as one of the risk factors of cardiovascular diseases (CVDs), type 2 diabetes mellitus (T2DM), and non-alcoholic fatty liver disease (NAFLD). Objective: The study aimed to investigate ...
Unraveling the Dysbiosis of Vaginal Microbiome to Understand Cervical Cancer Disease Etiology—An Explainable AI Approach
(
Multidisciplinary Digital Publishing Institute (MDPI)
, 2023 , Article)
Microbial Dysbiosis is associated with the etiology and pathogenesis of diseases. The studies on the vaginal microbiome in cervical cancer are essential to discern the cause and effect of the condition. The present study ...
Implications and theragnostic potentials of circular RNAs in rheumatic diseases
(
Elsevier
, 2023 , Article Review)
Circular RNAs (circRNAs), a class of non-coding RNAs (ncRNAs), are highly stable and ubiquitous molecules that exhibit tissue-specific expression. Accumulating evidence has shown that aberrant expression of circRNAs can ...
Management of chronic myeloid leukaemia: current treatment options, challenges, and future strategies.
(
taylor and francis online
, 2023 , Article)
Small molecule therapy is a critical component of targeted anticancer treatment, with tyrosine kinase inhibitors (TKIs) being the first compounds to treat the clonal Chronic Myelogenous Leukaemia (CML) translocation t ...
A new horizon in the phosphorylated sites of AGA: the structural impact of C163S mutation in aspartylglucosaminuria through molecular dynamics simulation
(
Taylor and Francis Ltd.
, 2023 , Article)
Aspartylglucosaminuria (AGU) is a lysosomal storage disorder caused by insufficient aspartylglucosaminidase (AGA) activity leading to chronic neurodegeneration. We utilized the PhosphoSitePlus tool to identify the AGA ...
Identification of potential circadian genes and associated pathways in colorectal cancer progression and prognosis using microarray gene expression analysis
(
Elsevier
, 2023 , Book chapter)
Colorectal cancer (CRC) is third cancer causing death in the world. CRC is associated with disrupting the circadian rhythm (CR), closely associating the CRC progression and the dysregulation of genes involved in the ...
Rational design of a multivalent vaccine targeting arthropod-borne viruses using reverse vaccinology strategies
(
Elsevier
, 2024 , Article)
Viruses transmitted by arthropods, such as Dengue, Zika, and Chikungunya, represent substantial worldwide health threats, particularly in countries like India. The lack of approved vaccines and effective antiviral therapies ...