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Regulation of NKG2D by RKIP: Implications on NK-mediated cytotoxicity and cytokine production
(
Elsevier
, 2021 , Book chapter)
RKIP (Raf kinase inhibitory protein) is a metastatic suppressor and a chemo-immuno-sensitizer. The deficiency or loss of RKIP has been linked with different cancer types, resulting in the activation of the MAPK pathway, ...
Information, Thermodynamics and Life: A Narrative Review
(
MDPI
, 2021 , Article Review)
Information is probably one of the most difficult physical quantities to comprehend. This applies not only to the very definition of information, but also to the physical entity of information, meaning how can it be ...
Silencing of Growth Differentiation Factor-15 Promotes Breast Cancer Cell Invasion by Down-regulating Focal Adhesion Genes.
(
International Institute of Anticancer Research
, 2020 , Article)
As metastasis accounts for most breast cancer (BC)-related deaths, identifying key players becomes research priority. Growth differentiation factor-15 (GDF15), a member of the transforming growth factor-β superfamily, is ...
Signatures of co-deregulated genes and their transcriptional regulators in colorectal cancer.
(
Nature Research
, 2020 , Article)
The deregulated genes in colorectal cancer (CRC) vary significantly across different studies. Thus, a systems biology approach is needed to identify the co-deregulated genes (co-DEGs), explore their molecular networks, and ...
ILK silencing inhibits migration and invasion of more invasive glioblastoma cells by downregulating ROCK1 and Fascin-1.
(
Springer
, 2020 , Article)
Glioblastoma multiforme (GBM) is the most aggressive type of brain tumor and it is associated with poor survival. Integrin-linked kinase (ILK) is a serine/threonine protein pseudo-kinase that binds to the cytoplasmic domains ...
Human papillomavirus E7 binds Oct4 and regulates its activity in HPV-associated cervical cancers.
(
Public Library of Science
, 2020 , Article)
Octamer binding transcription factor-4 (Oct4), is highly expressed in stem cells and has indispensable roles in pluripotency and cellular reprogramming. In contrast to other factors used for cellular reprogramming, a role ...
The Non-Coding RNA and Its Role in Tumor Therapy-Induced Resistance.
(
MDPI
, 2020 , Article)
The growth arrest-specific transcript 5 () is a >200-nt lncRNA molecule that regulates several cellular functions, including proliferation, apoptosis, invasion and metastasis, across different types of human cancers. Here, ...
High expression of immune checkpoints is associated with the TIL load, mutation rate and patient survival in colorectal cancer.
(
Spandidos Publications
, 2020 , Article)
Adoptive cell therapy with the use of tumor-infiltrating lymphocytes (TILs) is a very promising immunotherapeutic approach for the treatment of patients with colorectal cancer (CRC). However, within the tumor microenvironment, ...
New clinical approaches and emerging evidence on immune-checkpoint inhibitors as anti-cancer therapeutics: CTLA-4 and PD-1 pathways and beyond
(
Begell House Inc.
, 2019 , Article)
The development of immune checkpoint blockers, primarily comprising the anti-PD-1/anti-PD-L1 and anti-CTLA-4 monoclonal antibodies, has formed the therapeutic landscape of quite a few different cancer types. In spite of ...
Molecular correlates of immune cytolytic subgroups in colorectal cancer by integrated genomics analysis
(
Oxford University Press
, 2021 , Article)
Although immune checkpoint inhibition (ICI) has shown promising results in metastatic dMMR/MSI-H colorectal cancer (CRC), the majority of pMMR/MSS patients do not respond to such therapies. To systematically evaluate the ...