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Warfarin dosing strategies evolution and its progress in the era of precision medicine, a narrative review
(
Springer
, 2022 , Article Review)
Background For decades, vitamin K antagonists and specifically warfarin, have been the sole agents used orally to manage thromboembolic conditions, including stroke and venous thromboembolism (VTE). Several factors lead ...
Warfarin-Rifampin-Gene (WARIF-G) Interaction: A Retrospective, Genetic, Case–Control Study
(
Wiley-Blackwell
, 2023 , Article)
Warfarin is extensively metabolized by cytochrome P450 2C9 (CYP2C9). Concomitant use with the potent CYP2C9 inducer, rifampin, requires close monitoring and dosage adjustments. Although, in theory, warfarin dose increase ...
Preemptive Dose Adjustment Effect on the Quality of Anticoagulation Management in Warfarin Patients With Drug Interactions: A Retrospective Cohort Study
(
SAGE Publications Inc.
, 2019 , Article)
One strategy to manage patients on warfarin starting an interacting drug is to increase the frequency of monitoring. Another strategy is to adjust warfarin dose around the time patient is started on an interacting medication, ...
Rifampin-warfarin interaction in a mitral valve replacement patient receiving rifampin for infective endocarditis: a case report
(
SpringerOpen
, 2016 , Article)
Warfarin therapy is associated with many drug interactions that may cause a significant alteration in its anticoagulant effect. Rifampin is a widely used antimicrobial that has major interactions with several medications ...