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A lipidomic screen of hyperglycemia-treated HRECs links 12/15-Lipoxygenase to microvascular dysfunction during diabetic retinopathy via NADPH oxidase
(
American Society for Biochemistry and Molecular Biology
, 2015 , Article)
Retinal hyperpermeability and subsequent macular edema is a cardinal feature of early diabetic retinopathy (DR). Here, we investigated the role of bioactive lipid metabolites, in particular 12/15-lipoxygenase (LOX)-derived ...
Pigment epithelium-derived factor inhibits retinal microvascular dysfunction induced by 12/15-lipoxygenase-derived eicosanoids
(
Elsevier
, 2015 , Article)
We recently demonstrated that 12/15-lipoxygenase (LOX) derived metabolites, hydroxyeicosatetraenoic acids (HETEs), contribute to diabetic retinopathy (DR) via NADPH oxidase (NOX) and disruption of the balance in retinal ...
Association between Genetic Variants of GC Gene at 4q13.3 and Vitamin D Concentrations in Adult Females
(
Longdom
, 2019 , Article)
Background: Vitamin D binding protein, encoded by the GC gene (on 4q13.3), plays an important role in
transporting vitamin D. Several Genome-Wide Association Studies (GWASs) have established a significant
association ...
Metabolomic biomarkers of pancreatic cancer: a meta-analysis study
(
Impact Journals
, 2017 , Article)
Pancreatic cancer (PC) is an aggressive disease with high mortality rates,
however, there is no blood test for early detection and diagnosis of this disease.
Several research groups have reported on metabolomics based ...
12/15-Lipoxygenase-Derived Lipid Metabolites Induce Retinal Endothelial Cell Barrier Dysfunction: Contribution of NADPH Oxidase
(
Public Library of Science
, 2013 , Article)
The purpose of the current study was to evaluate the effect of 12/15- lipoxygenase (12/15-LOX) metabolites on retinal endothelial cell (REC) barrier function. FITC-dextran flux across the REC monolayers and electrical ...
Associations of Vitamin D Receptor Polymorphisms with Coronary Artery Diseases
(2016 , Poster)
Background:
Previous studies have investigated the association of rs1544410, rs7975232 and rs731236 polymorphisms on vitamin D receptor gene and its impact on diseases such as cancer, diabetes and hypertension in different ...
The Relationship Between Leptin and PCOS
(
De Gruyter
, 2014 , Conference Paper)
Background: The ob gene produces a leptin hormone that works
as a satiety signal to the hypothalamus. Leptin may have a role in polycystic ovary syndrome (PCOS) via its role on obesity and insulin resistance.
Materials ...
Retinopathy of Type 1 Diabetes in Arab Countries: Systematic Review and Meta-Analysis.
(
Karger
, 2018 , Article Review)
To conduct a systematic review and meta-analysis of retinopathy prevalence in patients with type 1 diabetes (T1D) in 22 Arab countries. We systematically searched 4 different literature databases (PubMed, Science Direct, ...
The prevalence of vitamin D deficiency among female college students at Qatar University
(
Medical Services Department Saudi Arabian Armed
, 2011 , Article)
Nowadays vitamin D deficiency is considered as a common problem among many Arab countries including Lebanon, Qatar, Saudi Arabia, UAE and other European countries as documented by many studies (1,2,3,5). Vitamin D is a ...
Lipidomics for the Prediction of the Unstable Coronary Plaque
(
Hamad bin Khalifa University Press (HBKU Press)
, 2016 , Conference Paper)
Plaques that build up in the lining of the coronary arteries are made up of lipids, inflammatory cells, smooth muscle cells and connective tissue. Thormbosis of a not necessarily occlusive but unstable plaque most often ...