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Organ-specific toxicity evaluation of stearamidopropyl dimethylamine (SAPDMA) surfactant using zebrafish embryos
(
Elsevier
, 2020 , Article)
Surfactants are widely used in the industry of detergents, household products, and cosmetics. SAPDMA is a cationic surfactant that is used mostly in cosmetics, conditioning agents and has recently gained attention as a ...
Biological screening of newly synthesized BIAN N-heterocyclic gold carbene complexes in zebrafish embryos
(
MDPI AG
, 2015 , Article)
N-Heterocyclic carbene (NHC) metal complexes possess diverse biological activities but have yet to be extensively explored as potential chemotherapeutic agents. We have previously reported the synthesis of a new class of ...
Biocompatibility and toxicity of novel iron chelator Starch-Deferoxamine (S-DFO) compared to zinc oxide nanoparticles to zebrafish embryo: An oxidative stress based apoptosis, physicochemical and neurological study profile.
(
Elsevier
, 2019 , Article)
Clinically approved iron chelators are effective in decreasing significant transfusional iron accumulation. Starch-Deferoxamine (S-DFO), a novel high molecular weight iron chelator, was produced to increase binding capacity ...
Computational modeling of motile cilia generated cerebral flow dynamics in zebrafish embryo
(
Qatar University Press
, 2020 , Poster)
Background: Motile cilia are hair-like microscopic structures which move the fluids along the epithelial surfaces. Cilia cover a wide range of regions in the nervous system, such as the nasal cavity, spinal cord central ...
Ecotoxicological assessment of Ti3C2Tx (MXene) using a zebrafish embryo model
(
Royal Society of Chemistry
, 2018 , Article)
The recent application of 2D Ti3C2Tx (MXene) nanomaterials as adsorbents and membranes for water treatment as well as for biomedical applications is attracting a growing interest. However, the environmental impact of MXene ...
Combine iron Chelation therapy ameliorates decline of iron on iron loaded Zebrafish embryo
(2017 , Conference Proceedings)
Thalassemia is the most common genetically inherited blood disorder in the world arisen
from defect in hemoglobin production, resulting in ineffective erythropoiesis and rapid destruction
of RBC in the periphery that ...
Toxicity Evaluation of Stearamidopropyl Dimethylamine Surfactant on Embryonic Development of Zebrafish
(
Qatar University Press
, 2020 , Poster)
Background: Surfactants best known for their use in the industry of detergents, household products, and cosmetics. Usually, the amount of released surfactants into the environment is diluted during secondary water treatment. ...
In Vivo Investigation of Cardiac Benefits of Sodium Glucose Cotransporter Inhibition Using the Zebrafish Model
(
Qatar University Press
, 2020 , Poster)
Type 2 diabetes mellitus (T2DM) affects >16% of adults in Qatar. Newly emerging class of antidiabetic drugs focuses on SGLT inhibition were observed to reduce CVDs risks in diabetic patients. Up to date, the mechanism ...
Development and In Vivo Testing of Smart Nanoparticles for Enhanced Anti-Cancer Activity and Reduced Cardiotoxicity Associated with Tyrosine Kinase Inhibitors
(
Qatar University Press
, 2021 , Poster)
Tyrosine kinase inhibitors (TKIs) are new generation of anti-cancer drugs with very high efficiency against cancer cells. However, TKIs are associated with severe cardiotoxicity limiting their clinical benefits. One TKI ...
Ecotoxicological assessment of two surfactant on the emryonic development
(
Qatar University Press
, 2021 , Poster)
In this study, zebrafish (Danio rerio) embryos was served as a model for marine fauna to determine if there is any potential of organ-specific toxicity (neuromuscular, hepatic, cytotoxic, and cardiac) caused by Silicone-Q-22 ...