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    Sanguinarine Induces Apoptosis in Papillary Thyroid Cancer Cells via Generation of Reactive Oxygen Species. 

    Khan, Abdul Q; Mohamed, Elham A N; Hakeem, Ishrat; Nazeer, Aneeza; Kuttikrishnan, Shilpa; Prabhu, Kirti S; Siveen, Kodappully S; Nawaz, Zafar; Ahmad, Aamir; Zayed, Hatem; Uddin, Shahab... more authors ... less authors ( MDPI , 2020 , Article)
    Sanguinarine (SNG), a natural compound with an array of pharmacological activities, has promising therapeutic potential against a number of pathological conditions, including malignancies. In the present study, we have ...
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    Bladder neoplasms and NF-κB: an unfathomed association. 

    Jebaraj Walter, Charles Emmanuel; Durairajan, Sankari; Periyandavan, Kalaiselvi; Priya Doss C, George; Davis G, Dicky John; Vasanthi A, Hannah Rachel; Johnson, Thanka; Zayed, Hatem... more authors ... less authors ( Taylor & Francis , 2020 , Article)
    Bladder cancer is the second most common genitourinary tract cancer and is often recurrent and/or chemoresistant after tumor resection. Cigarette smoking, exposure to aromatic amines, and chronic infection/inflammation are ...
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    Molecular dynamics simulations to decipher the structural and functional consequences of pathogenic missense mutations in the galactosylceramidase (GALC) protein causing Krabbe's disease. 

    Thirumal Kumar, D; Jain, Nikita; Udhaya Kumar, S; Jena, Prangya Paramita; Ramamoorthy, Siva; George Priya Doss, C; Zayed, Hatem... more authors ... less authors ( Taylor & Francis , 2020 , Article)
    Krabbe disease (KD), also known as globoid cell leukodystrophy disease, is an autosomal recessive lysosomal storage genetic disorder, which is caused by the deficiecncy of galactocerebrosidase (GALC) coding gene (). This ...
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    Protective Effect of Cyclically Pressurized Solid⁻Liquid Extraction Polyphenols from Grape Pomace on Oxidative Endothelial Cell Death. 

    Posadino, Anna Maria; Biosa, Grazia; Zayed, Hatem; Abou-Saleh, Haissam; Cossu, Annalisa; Nasrallah, Gheyath K; Giordo, Roberta; Pagnozzi, Daniela; Porcu, Maria Cristina; Pretti, Luca; Pintus, Gianfranco... more authors ... less authors ( MDPI , 2018 , Article)
    The aim of this work is the evaluation of a green extraction technology to exploit winery waste byproducts. Specifically, a solid⁻liquid extraction technology (Naviglio Extractor) was used to obtain polyphenolic antioxidants ...
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    Krabbe Disease in the Arab World 

    Zayed, Hatem ( IOS Press , 2015 , Article)
    The autosomal recessive inherited Krabbe disease (KD) is a devastating pediatric lysosomal storage disorder affecting white matter of the brain. It is caused by mutations in the gene coding for the lysosomal enzyme ...
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    Clinical Exome Sequencing unravels new disease-causing mutations in the myeloproliferative neoplasms: A pilot study in patients from the state of Qatar. 

    Al-Dewik, Nader; Ben-Omran, Tawfeg; Zayed, Hatem; Trujillano, Daniel; Kishore, Shivendra; Rolfs, Arndt; Yassin, Mohamed A... more authors ... less authors ( Elsevier , 2018 , Article)
    Clinical Exome Sequencing (CES) has increasingly become a popular diagnostic tool in patients suffering from genetic disorders that are clinically and genetically complicated. Myeloproliferative Neoplasms (MPNs) is an ...
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    Neuropathy of type 1 diabetes in the Arab world: A systematic review and meta-analysis 

    Abdel-Motal, Ussama M.; Abdelalim, Essam M.; Abou-Saleh, Haissam; Zayed, Hatem ( Elsevier , 2017 , Article)
    Abstract AimsAlthough type 1 diabetes (T1D) is a common disease in the Arab nations, there is no data available on the prevalence of peripheral neuropathy (PN) among T1D subjects in Arab countries. The aim of this study ...
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    Structural Analysis of G1691S Variant in the Human Filamin B Gene Responsible for Larsen Syndrome: A Comparative Computational Approach 

    P., Sneha; D., Kumar Thirumal; Tanwar, Himani; R., Siva; C., George Priya Doss; Zayed, Hatem... more authors ... less authors ( Wiley Periodicals, Inc , 2017 , Article)
    Larsen syndrome (LRS) is a rare genetic disease associated with variable manifestations including skeletal malformations, dislocations of the large joints, and notable changes in facial and limb features. Genetic variants ...
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    Inositol 1,4,5-Trisphosphate Receptors in Hypertension. 

    Eid, Ali H; El-Yazbi, Ahmed F; Zouein, Fouad; Arredouani, Abdelilah; Ouhtit, Allal; Rahman, Md M; Zayed, Hatem; Pintus, Gianfranco; Abou-Saleh, Haissam... more authors ... less authors ( Frontiers Media , 2018 , Article Review)
    Chronic hypertension remains a major cause of global mortality and morbidity. It is a complex disease that is the clinical manifestation of multiple genetic, environmental, nutritional, hormonal, and aging-related disorders. ...
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    Determining the role of missense mutations in the POU domain of HNF1A that reduce the DNA-binding affinity: A computational approach 

    P., Sneha; D., Thirumal Kumar; C., George Priya Doss; R., Siva; Zayed, Hatem ( Plos One , 2017 , Article)
    Maturity-onset diabetes of the young type 3 (MODY3) is a non-ketotic form of diabetes associated with poor insulin secretion. Over the past years, several studies have reported the association of missense mutations in the ...
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      Zayed, Hatem (104) George Priya Doss, C. (25) Thirumal Kumar, D. (18) n 2009210819 (17) ... View More
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