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Signatures of co-deregulated genes and their transcriptional regulators in colorectal cancer.
(
Nature Research
, 2020 , Article)
The deregulated genes in colorectal cancer (CRC) vary significantly across different studies. Thus, a systems biology approach is needed to identify the co-deregulated genes (co-DEGs), explore their molecular networks, and ...
High expression of immune checkpoints is associated with the TIL load, mutation rate and patient survival in colorectal cancer.
(
Spandidos Publications
, 2020 , Article)
Adoptive cell therapy with the use of tumor-infiltrating lymphocytes (TILs) is a very promising immunotherapeutic approach for the treatment of patients with colorectal cancer (CRC). However, within the tumor microenvironment, ...
Molecular correlates of immune cytolytic subgroups in colorectal cancer by integrated genomics analysis
(
Oxford University Press
, 2021 , Article)
Although immune checkpoint inhibition (ICI) has shown promising results in metastatic dMMR/MSI-H colorectal cancer (CRC), the majority of pMMR/MSS patients do not respond to such therapies. To systematically evaluate the ...