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A low glycemic diet protects disease-prone Nrf2-deficient mice against age-related macular degeneration.
(
Elsevier
, 2020 , Article)
Age-related macular degeneration (AMD) is a major blinding disease, affecting over 14% of the elderly. Risk for AMD is related to age, diet, environment, and genetics. Dietary modulation of AMD risk is a promising treatment ...
Blood biomarkers associated with autism spectrum disorder may provide early diagnosis
(
Qatar University Press
, 2020 , Poster)
Autism Spectrum Disorders (ASD) are a collection of neuropsychiatric disorders. ASD affects 1 in 87 in Qatar and is expected to increase. The high variability and heterogeneity of the symptoms makes diagnosis of ASD difficult ...
Protein Glycation in Plants-An Under-Researched Field with Much Still to Discover.
(
MDPI
, 2020 , Article)
Recent research has identified glycation as a non-enzymatic post-translational modification of proteins in plants with a potential contributory role to the functional impairment of the plant proteome. Reducing sugars with ...
Vulnerabilities of the SARS-CoV-2 virus to proteotoxicity - opportunity for repurposed chemotherapy of COVID-19 infection
(
Qatar University Press
, 2020 , Poster)
The global pandemic of COVID-19 disease caused by infection with the SARS-CoV-2 coronavirus, has produce an urgent requirement and search for improved treatments whilst effective vaccines are developed. A strategy for ...
High fractional excretion of glycation adducts is associated with subsequent early decline in renal function in type 1 diabetes
(
Nature Publishing Group
, 2020 , Article)
Increased protein glycation, oxidation and nitration is linked to the development of diabetic nephropathy. We reported levels of serum protein glycation, oxidation and nitration and related hydrolysis products, glycation, ...
Reading patterns of proteome damage by glycation, oxidation and nitration: quantitation by stable isotopic dilution analysis LC-MS/M
(
Portland Press
, 2020 , Article Review)
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) provides a high sensitivity, high specificity multiplexed method for concurrent detection of adducts formed by protein glycation, oxidation and nitration, also ...
Evaluation of antiviral activity of Manuka honey against SARS-CoV-2.
(
Qatar University Press
, 2021 , Poster)
Background and aims: In 2020 a global pandemic was declared caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2). The pandemic is still ongoing and continues to cause considerable mortality and morbidity ...
Risk prediction of early decline in renal function in diabetic kidney disease with algorithm including fractional excretion of glycated amino acids
(
Qatar University Press
, 2021 , Poster)
Background and aims: Diabetic kidney disease occurs in ca. 40% patients with diabetes. Approximately 1 in 5 patients with type 1 diabetes mellitus (T1DM) and 1 in 3 patients with type 2 diabetes mellitus (T2DM) develop ...
Antiviral activity of glucose-derived reactive metabolite, methylglyoxal against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
(
Hamad bin Khalifa University Press (HBKU Press)
, 2022 , Article)
Background: The ongoing coronavirus disease 2019 (COVID-19) pandemic has resulted in a global health emergency. With incomplete vaccination and incomplete protection of the vaccinated population, there remains an urgent ...
Dicarbonyl stress, protein glycation and the unfolded protein response
(
Springer
, 2021 , Article Review)
The reactive dicarbonyl metabolite, methylglyoxal (MG), is increased in obesity and diabetes and is implicated in the development of insulin resistance, type 2 diabetes mellitus and vascular complications of diabetes. ...