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    Determining the role of missense mutations in the POU domain of HNF1A that reduce the DNA-binding affinity: A computational approach 

    P., Sneha; D., Thirumal Kumar; C., George Priya Doss; R., Siva; Zayed, Hatem ( Plos One , 2017 , Article)
    Maturity-onset diabetes of the young type 3 (MODY3) is a non-ketotic form of diabetes associated with poor insulin secretion. Over the past years, several studies have reported the association of missense mutations in the ...
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    Structural Analysis of G1691S Variant in the Human Filamin B Gene Responsible for Larsen Syndrome: A Comparative Computational Approach 

    P., Sneha; D., Kumar Thirumal; Tanwar, Himani; R., Siva; C., George Priya Doss; Zayed, Hatem... more authors ... less authors ( Wiley Periodicals, Inc , 2017 , Article)
    Larsen syndrome (LRS) is a rare genetic disease associated with variable manifestations including skeletal malformations, dislocations of the large joints, and notable changes in facial and limb features. Genetic variants ...
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    Neuropathy of type 1 diabetes in the Arab world: A systematic review and meta-analysis 

    Abdel-Motal, Ussama M.; Abdelalim, Essam M.; Abou-Saleh, Haissam; Zayed, Hatem ( Elsevier , 2017 , Article)
    Abstract AimsAlthough type 1 diabetes (T1D) is a common disease in the Arab nations, there is no data available on the prevalence of peripheral neuropathy (PN) among T1D subjects in Arab countries. The aim of this study ...
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    Potential routes of spread of Zika virus to the Middle East, North Africa and Asia: Action must be taken 

    Zayed, Hatem; Doss C, George Priya; El Zowalaty, Mohamed Ezzat ( Future Medicine Ltd. , 2017 , Article Review)
    [No abstract available]
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    Comparative computational assessment of the pathogenicity of mutations in the Aspartoacylase enzyme 

    George Priya Doss, C.; Zayed, Hatem ( Springer US , 2017 , Article)
    Aspartoacylase (ASPA) is a zinc-dependent abundant enzyme in the brain, which catalyzes the conversion of N-acetyl aspartate (NAA) into acetate and aspartate. Mutations in the ASPA gene are associated with the development ...
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    Two patients with Canavan disease and structural modeling of a novel mutation. 

    Zaki, Osama K; Krishnamoorthy, Navaneethakrishnan; El Abd, Heba S; Harche, Soumaya A; Mattar, Reem A; Al Disi, Rana S; Nofal, Mariam Y; El Bekay, Rajaa; Ahmed, Khalid A; George Priya Doss, C; Zayed, Hatem... more authors ... less authors ( Springer US , 2017 , Article)
    Canavan disease (CD) is a rare fatal childhood neurological autosomal recessive genetic disease caused by mutations in the ASPA gene, which lead to catalytic deficiency of the ASPA enzyme, which catalyzes the hydrolysis ...
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    Differences in the neovascular potential of thymus versus subcutaneous adipose-derived stem cells from patients with myocardial ischemia. 

    Oliva-Olivera, Wilfredo; Coín-Aragüez, Leticia; Lhamyani, Said; Salas, Julián; Gentile, Adiana-Mariel; Romero-Zerbo, Silvana-Yanina; Zayed, Hatem; Valderrama, J F; Tinahones, Francisco José; Bekay, Rajaa E L... more authors ... less authors ( Wiley , 2017 , Article)
    Adipose tissue-derived multipotent mesenchymal cells (ASCs) participate in the formation of blood vessels under hypoxic conditions. It is probable that the susceptibility of ASCs to the influence of age and aging-associated ...
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    A profound computational study to prioritize the disease-causing mutations in PRPS1 gene. 

    Agrahari, Ashish Kumar; Sneha, P; George Priya Doss, C; Siva, R; Zayed, Hatem ( Springer Verlag , 2017 , Article)
    Charcot-Marie-Tooth disease (CMT) is one of the most commonly inherited congenital neurological disorders, affecting approximately 1 in 2500 in the US. About 80 genes were found to be in association with CMT. The phosphoribosyl ...
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    Genotype-phenotype correlation in patients with isovaleric acidaemia: comparative structural modelling and computational analysis of novel variants. 

    Zaki, Osama K; Priya Doss C, George; Ali, Salsabil A; Murad, Ghadeer G; Elashi, Shaima A; Ebnou, Maryam S A; Kumar D, Thirumal; Khalifa, Ola; Gamal, Radwa; El Abd, Heba S A; Nasr, Bilal N; Zayed, Hatem... more authors ... less authors ( Oxford University Press (OUP) , 2017 , Article)
    Isovaleric acidaemia (IVA) is an autosomal recessive inborn error of leucine metabolism. It is caused by a deficiency in the mitochondrial isovaleryl-CoA dehydrogenase (IVD) enzyme. In this study, we investigated eight ...
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    Structural Determination of the Broadly Reactive Anti-IGHV1-69 Anti-idiotypic Antibody G6 and Its Idiotope 

    Avnir, Yuval; Prachanronarong, Kristina L; Zhang, Zhen; Hou, Shurong; Peterson, Eric C; Sui, Jianhua; Zayed, Hatem; Kurella, Vinodh B; McGuire, Andrew T; Stamatatos, Leonidas; Hilbert, Brendan J; Bohn, Markus-Frederik; Kowalik, Timothy F; Jensen, Jeffrey D; Finberg, Robert W; Wang, Jennifer P; Goodall, Margaret; Jefferis, Roy; Zhu, Quan; Kurt Yilmaz, Nese; Schiffer, Celia A; Marasco, Wayne A... more authors ... less authors ( Elsevier (Cell Press) , 2017 , Article)
    The heavy chain IGHV1-69 germline gene exhibits a high level of polymorphism and shows biased use in protective antibody (Ab) responses to infections and vaccines. It is also highly expressed in several B cell malignancies ...
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    Author
    • Zayed, Hatem (8)
    • n 2009210819 (3) Zaki, Osama K (3) Zayed, Hatem (3) ... View More
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      Article (10) Article Review (1)
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      Aspartoacylase (2) Canavan disease (2) Genotype-phenotype correlation (2) Molecular dynamics simulation (2) ... View More
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    • 2017 (11)
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