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Intercellular Communication in Cancer
(
Springer
, 2023 , Book chapter)
Junctional complexes play a central role in maintaining tissue hemostasis. The barrier function of epithelial cells, that maintain tissues coherence and coordination of cellular synchronicity, is a consequence of a junctional ...
Ubiquitin-Related Modifier 1 (URM-1) Modulates Cx43 in Breast Cancer Cell Lines.
(
MDPI
, 2023 , Article)
Gap-junction-forming connexins are exquisitely regulated by post-translational modifications (PTMs). In particular, the PTM of connexin 43 (Cx43), a tumor suppressor protein, regulates its turnover and activity. Here, we ...
Traumatic Brain Injury Can Affect Emotions and Behaviors
(
Frontiers Media
, 2023 , Article)
Proper brain functioning is responsible for our feelings, behavior, and thinking. However, an injury to the brain can disrupt brain function, which can affect our emotions and behaviors. A traumatic brain injury (TBI) can ...
Epac as a tractable therapeutic target
(
Elsevier
, 2023 , Article)
In 1957, cyclic adenosine monophosphate (cAMP) was identified as the first secondary messenger, and the first signaling cascade discovered was the cAMP-protein kinase A (PKA) pathway. Since then, cAMP has received increasing ...
Cancer Metastasis: Dynamic Hetero-cellular Communications Between Cancer Cells and Host Tissues
(
Springer International Publishing
, 2023 , Book chapter)
Metastasis is the most devastating aspect of cancer. Originally, tumor cells arise from a single clone, and then they undergo additional mutations and acquire invasive and metastatic features. These acquired mutations are ...
Nano-Engineering in Traumatic Brain Injury
(
Wiley
, 2023 , Book chapter)
Traumatic brain injury (TBI) is a leading cause of mortality and chronic disability worldwide TBI involves an initial primary phase triggered by an impactful force to the brain and a subsequent secondary pathological phase. ...
Unveiling a Biomarker Signature of Meningioma: the Need for a Panel of Genomic, Epigenetic, Proteomic, and RNA Biomarkers to Advance Diagnosis and Prognosis
(
preprints
, 2023 , Preprint)
Meningiomas are the most prevalent primary intracranial tumors. The majority are benign but can undergo dedifferentiation in grades classified from I to III. Meningiomas tremendous variability in tumor behavior and slow ...
Biological applications of imiquimod analogues: An update (Review)
(
Spandidos Publications
, 2023 , Article Review)
The last decade witnessed intensive efforts in drug discovery and the emergence of thousands of molecules with potential for use as therapeutic targets. However, only a few hundred of these molecules reached the stage of ...
3D hydrogel/ bioactive glass scaffolds in bone tissue engineering: Status and future opportunities
(
Elsevier
, 2023 , Article Review)
Repairing significant bone defects remains a critical challenge, raising the clinical demand to design novel bone biomaterials that incorporate osteogenic and angiogenic properties to support the regeneration of vascularized ...
Biochemical and cellular basis of oxidative stress: Implications for disease onset
(
Wiley
, 2023 , Article Review)
Cellular oxidation–reduction (redox) systems, which encompass pro- and antioxidant molecules, are integral components of a plethora of essential cellular processes. Any dysregulation of these systems can cause molecular ...