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AuthorZhang, Yu
AuthorYue, Qin
AuthorJiang, Yongjian
AuthorLuo, Wei
AuthorElzatahry, Ahmed A.
AuthorAlghamdi, Abdulaziz
AuthorDeng, Yonghui
AuthorZhao, Dongyuan
Available date2021-09-08T06:49:46Z
Publication Date2016
Publication NameCrystEngComm
AbstractIn this study, novel mesoporous siliceous vesicles with ultrathin walls (50 nm in thickness) and large cavities were synthesized through a facile biliquid-interface co-assembly method by using cetyltrimethylammonium bromide as a structure-directing agent and tetraethoxysilane as a silica source. Various synthesis parameters (stirring rate, ionic strength, reaction temperature) have been investigated and were found to affect the interface co-assembly process. The obtained vesicles are highly water-dispersible and have large mesopores (6.7 nm) in the walls, high surface area (902 m2 g-1) and large pore volume (1.57 cm3 g-1). Cytotoxicity experiments and cellular uptake studies based on fluorescence imaging indicate that the obtained vesicles possess excellent biocompatibility and can be readily internalized by Pan02 cells due to their good water dispersibility and affinity to cell membranes. The outstanding properties of the obtained mesoporous silica vesicles make them good candidates for various bio-applications, such as drug delivery and enzyme immobilization. 2016 The Royal Society of Chemistry.
SponsorThis work was supported by the National Natural Science Foundation of China (no. 51402049, 51372041 and 51422202), the Shanghai Committee of Science and Technology (14ZR1400600 and 13140902401), the Fundamental Research Funds for the Central Universities (2232015D3-06), the "Shu Guang" project (13SG02) of Shanghai Municipal Education Commission, Program for New Century Excellent Talents in University (NCET-12-0123), the National Youth Top Talent Support Program of the National High-level Personnel of Special Support Program, and Qatar University startup grant no. QUSG-CAS-MST-14-15-1. We extend our appreciation to the Deanship of Scientific Research at King Saud University for funding this work through the research group project no. RGP-227.
PublisherRoyal Society of Chemistry
TitleA facile biliquid-interface co-assembly synthesis of mesoporous vesicles with large pore sizes
Issue Number23
Volume Number18

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