Higher Dietary Se Intake Is Associated With the Risk of New-Onset Fracture: A National Longitudinal Study for 20 Years
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Date
2021-08Author
Zhang, YangchangYe, Mengliang
Zhao, Yong
Xiong, Yang
Shen, Shisi
Yu, Qiuhua
Lu, Yanjun
Shi, Zumin
Lei, Xun
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Background: The association between dietary selenium (Se) intake and
osteoporosis-related fractures remains inconsistent. We aimed to examine the dose
relationship between Se intake and incident fracture among Chinese adults.
Methods: The dietary data were retrieved from the China Health and Nutrition Survey
conducted between 1991 and 2011, and 17,150 participants aged above 20 were
included. A 3-day, 24-h recall of food intake was performed to assess cumulative average
dietary Se intake. The fracture was based on self-report in each survey between 1997
and 2011. The association between Se intake and fracture was tested by Cox regression,
and the non-linear association was examined by restricted cubic splines (RCS).
Results: There were 976 fracture cases during a mean of 10.2 years follow-up. In a fully
adjusted Cox model, across the quartiles of Se intake, the hazard ratios (HRs) for fracture
were 1.07 (95% CI .86–1.33), 1 (reference), 1.25 (95% CI 1.02–1.53), and 1.33 (95% CI
1.07–1.65). RCS showed a parabolic association (P non-linear = 0.037) between Se and
fracture for men as well as a U-shape dose-response (P non-linear = 0.04) between Se
and fracture for subjects living in highly urbanized areas.
Conclusion: In conclusion, there is a non-linear association between selenium intake
and fracture, with higher intake associated with increased risk. The shape of the
association varies by gender and urbanization level.
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