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المؤلفAl-Waeli, Haider
المؤلفReboucas, Ana Paula
المؤلفMansour, Alaa
المؤلفMorris, Martin
المؤلفTamimi, Faleh
المؤلفNicolau, Belinda
تاريخ الإتاحة2021-09-30T09:10:49Z
تاريخ النشر2021-12-01
اسم المنشورSystematic Reviews
المعرّفhttp://dx.doi.org/10.1186/s13643-021-01690-w
الاقتباسAl-Waeli, H., Reboucas, A.P., Mansour, A. et al. Non-steroidal anti-inflammatory drugs and bone healing in animal models—a systematic review and meta-analysis. Syst Rev 10, 201 (2021). https://doi.org/10.1186/s13643-021-01690-w
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85109717503&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/23582
الملخصBackground: Non-steroidal anti-inflammatory drugs (NSAID) have excellent anti-inflammatory and analgesic properties and are extensively used to treat post-traumatic or surgical musculoskeletal pain. Although an extensive literature exists on the administration of NSAID on animal bone healing, no systematic review and meta-analysis of animal studies that investigate the effect of NSAID administration on bone fracture healing. Objective of this study is to conduct a systematic review and meta-analysis to estimate the effect of NSAIDs administration on bone healing biomechanical and histomorphometric measurements in different animal models after bone fracture surgery. Methods: We performed a systematic review and meta-analysis of animal studies to estimate the effect of NSAID administration after bone fracture on healing outcomes. We searched eight databases without limiting the search to starting date up to 1 February 2021 for articles on fractured bone healing in animal models in which NSAID were administered. Results: Out of 6732 articles screened, 47 were included and 3 common bone healing outcomes were analysed: biomechanical properties (maximum force to break, stiffness, and work-to-failure), micro-computed tomography (μ-CT), and histomorphometric measurements. The studies were generally of low-quality scores because crucial information, especially concerning randomization, blinding, and allocation concealment, was poorly reported. Our results show that the negative effects of NSAID after bone fracture on certain biomechanical properties of the healing bones was not statistically significant in mice compared with other animals, in females compared with males, and in younger compared with older animals. Conclusion: The findings demonstrated that NSAIDs administration decreased the biomechanical properties of healing bones after fracture surgery in comparison to the control group. Moreover, different effect on certain outcomes was detected among different sites, sex of the animals, and the time of assessment. Trial registration: Protocol published and registered in SYstematic Review Center for Laboratory animal Experimentation (SYRCLE) in 2017, https://www.radboudumc.nl/getmedia/757ec408-7a9e-4635-8233-ae951effea54/Non-Steroidal-Anti-inflammatory-Drugs-and-bone-healing-in-animal-Models-Systematic-Review-and-Meta-Analysis.aspx
اللغةen
الناشرBMC
الموضوعBone
Cyclooxygenase
Fracture
NSAID
Prostaglandin
Systematic review and meta-analysis
العنوانNon-steroidal anti-inflammatory drugs and bone healing in animal models-a systematic review and meta-analysis
النوعArticle
رقم العدد1
رقم المجلد10
ESSN2046-4053
dc.accessType Open Access


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