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    Missing and unerupted teeth in osteogenesis imperfecta

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    1-s2.0-S8756328221001733-main.pdf (1.532Mb)
    Date
    2021-09-30
    Author
    Doaa, Taqi
    Moussa, Hanan
    Schwinghamer, Timothy
    Vieira, Alexandre Rezende
    Dagdeviren, Didem
    Retrouvey, Jean-Marc
    Rauch, Frank
    Tamimi, Faleh
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    Abstract
    IntroductionOsteogenesis imperfecta (OI) is a genetic disorder characterized by bone fragility and craniofacial and dental abnormalities such as congenitally missing teeth and teeth that failed to erupt which are believed to be doubled in OI patients than normal populations and were associated with low oral health quality of life. However, the etiology of these abnormalities remains unclear. To understand the factors influencing missing and unerupted teeth, we investigated their prevalence in a cohort of OI patients as a function of the clinical phenotype (OI type), the genetic variant type, the tooth type and the onset of bisphosphonate treatment. MethodA total of 144 OI patients were recruited from The Shriners Hospital, Montreal, Canada, between 2016 and 2017. Patients were evaluated using intraoral photographs and panoramic radiographs. Missing teeth were evaluated in all patients, and unerupted teeth were assessed only in patients ≥15 years old (n = 82). ResultsOn average, each OI patient had 2.4 missing teeth and 0.8 unerupted teeth, and the most common missing and unerupted teeth were the premolars and the upper second molars, respectively. These phenomena were more prominent in OI type III and IV than in OI type I, and were not sex or age-related. Missing teeth were significantly more common in patients with C-propeptide variants than all other variants (p-value <0.05). Unerupted teeth were significantly more common in patients with α1 and α2 glycine variants or substitutions than in those with haploinsufficiency variants. Early-onset of bisphosphonate treatment would significantly increase the risk of unerupted teeth in patients with OI types III and IV (OR = 1.68, 95% CI (1.15–1.53)). ConclusionThe prevalence of missing and unerupted teeth at the tooth type level in OI patients varies according to the nature of the collagen variants and the OI type. These findings highlight the role of collagen in tooth development and eruption.
    URI
    https://www.sciencedirect.com/science/article/pii/S8756328221001733
    DOI/handle
    http://dx.doi.org/10.1016/j.bone.2021.116011
    http://hdl.handle.net/10576/23583
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    • Dental Medicine Research [‎424‎ items ]

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